Prevalence of peripheral artery disease (PAD) and factors associated: An epidemiological analysis from the population-based Screening PRE-diabetes and type 2 DIAbetes (SPREDIA-2) study
| Autor: | Concesa Sabín, Eva Estirado, José María Mostaza, D Vicent, V. Sánchez-Arroyo, Pedro J. Fernandez-Garcia, Juan Carlos Abánades-Herranz, Paloma Gómez-Campelo, Belén Fernández-Puntero, Francisca García-Iglesias, C. de Burgos-Lunar, L. Montesano-Sánchez, J.M. de Miguel-Yanes, Teresa González-Alegre, Sonsoles Paloma Luquero López, Fernando Laguna, P Patrón, Carlos Lahoz, Miguel A. Salinero-Fort, V Cornejo Del Río |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Population lcsh:Medicine Type 2 diabetes 030204 cardiovascular system & hematology Estado Prediabético Prediabetic State 03 medical and health sciences chemistry.chemical_compound Peripheral Arterial Disease 0302 clinical medicine Internal medicine Diabetes mellitus Enfermedad Arterial Periférica Medicine Humans 030212 general & internal medicine Peripheral artery disease (PAD) education lcsh:Science Aged education.field_of_study Multidisciplinary business.industry lcsh:R Odds ratio Middle Aged medicine.disease Surgery Pulse pressure Blood pressure chemistry Diabetes Mellitus Type 2 Uric acid Female lcsh:Q business Research Article |
| Zdroj: | PLoS ONE, Vol 12, Iss 10, p e0186220 (2017) Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Aim To describe the prevalence of Peripheral Artery Disease (PAD) in a random population sample and to evaluate its relationship with Mediterranean diet and with other potential cardiovascular risk factors such as serum uric acid and pulse pressure in individuals ranged 45 to 74 years. Methods Cross-sectional analysis of 1568 subjects (mean age 6.5 years, 43% males), randomly selected from the population. A fasting blood sample was obtained to determine glucose, lipids, and HbA1C levels. An oral glucose tolerance test was performed in non-diabetic subjects. PAD was evaluated by ankle-brachial index and/or having a prior diagnosis. Results PAD prevalence was 3.81% (95% CI, 2.97-4.87) for all participants. In men, PAD prevalence was significantly higher than in women [5.17% (95% CI, 3.74-7.11) vs. 2.78% (95% CI, 1.89-4.07); p = 0.014]. Serum uric acid in the upper quartile was associated with the highest odds ratio (OR) of PAD (for uric acid > 6.1 mg/dl, OR = 4.31; 95% CI, 1.49-12.44). The remaining variables more strongly associated with PAD were: Heart rate >90 bpm (OR = 4.16; 95%CI, 1.62-10.65), pulse pressure in the upper quartile (≥ 54 mmHg) (OR = 3.82; 95%CI, 1.50-9.71), adherence to Mediterranean diet (OR = 2.73; 95% CI, 1.48-5.04), and former smoker status (OR = 2.04; 95%CI, 1.00-4.16). Conclusions Our results show the existence of a low prevalence of peripheral artery disease in a population aged 45-74 years. Serum uric acid, pulse pressure and heart rate >90 bpm were strongly associated with peripheral artery disease. The direct association between Mediterranean diet and peripheral artery disease that we have found should be evaluated through a follow-up study under clinical practice conditions. |
| Databáze: | OpenAIRE |
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