Treatment of Mucosa-associated Lymphoid Tissue Lymphoma in Sjogren's Syndrome
| Autor: | Jan L. N. Roodenburg, Arjan Vissink, Philip M. Kluin, Fred K. L. Spijkervet, Gustaaf W. van Imhoff, Hendrika Bootsma, Rodney P. E. Pollard, Cees G. M. Kallenberg, J. Pijpe |
|---|---|
| Přispěvatelé: | Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Personalized Healthcare Technology (PHT), Stem Cell Aging Leukemia and Lymphoma (SALL), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
CHOP CHEMOTHERAPY CONCERTED ACTION medicine.medical_treatment Gastroenterology Antibodies Monoclonal Murine-Derived INVOLVED-FIELD RADIOTHERAPY immune system diseases hemic and lymphatic diseases MALIGNANT-LYMPHOMA Parotid Gland Immunology and Allergy SJOGREN'S SYNDROME B-cell lymphoma Aged 80 and over MALT lymphoma Middle Aged Combined Modality Therapy Parotid Neoplasms Parotid gland Treatment Outcome medicine.anatomical_structure RITUXIMAB MONOTHERAPY Disease Progression Female Rituximab medicine.symptom medicine.drug Adult medicine.medical_specialty Immunology MALT LYMPHOMA Antineoplastic Agents Asymptomatic Rheumatology Internal medicine medicine Humans NON-HODGKINS-LYMPHOMA Watchful Waiting Aged Retrospective Studies RESPONSE CRITERIA Chemotherapy business.industry MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA ANTI-CD20 MONOCLONAL-ANTIBODY B-CELL LYMPHOMA Lymphoma B-Cell Marginal Zone medicine.disease Lymphoma Surgery business Watchful waiting |
| Zdroj: | Journal of Rheumatology, 38(10), 2198-2208. J RHEUMATOL PUBL CO |
| ISSN: | 0315-162X |
| DOI: | 10.3899/jrheum.110077 |
| Popis: | Objective.To retrospectively analyze the clinical course of patients with mucosa-associated lymphoid tissue (MALT)-type lymphoma of the parotid gland and associated Sjögren’s syndrome (SS).Methods.All consecutive patients with SS and MALT lymphoma (MALT-SS) diagnosed in the University Medical Center Groningen between January 1997 and January 2009 were analyzed. Clinical course and treatment outcome of SS and MALT lymphoma were evaluated.Results.From a total of 329 patients with SS, 35 MALT-SS patients were identified, with a median followup of 76 months (range 16–153 mo). MALT lymphoma was localized in the parotid gland in all cases. Treatment consisted of “watchful waiting” (n = 10), surgery (n = 3), radiotherapy (n = 1), surgery combined with radiotherapy (n = 2), rituximab only (n = 13), or rituximab combined with chemotherapy (n = 6). Complete response was observed in 14 patients, partial response in 1 patient, and stable disease in 20 patients. In 6 of 7 patients with initially high SS disease activity (M-protein, cryoglobulins, IgM rheumatoid factor > 100 KIU/l, severe extraglandular manifestations), MALT lymphoma progressed and/or SS disease activity increased after a median followup of 39 months (range 4–98 mo), necessitating retreatment. Only 1 patient with MALT who had low SS disease activity showed progression of lymphoma when left untreated.Conclusion.An initially high SS disease activity likely constitutes an adverse prognostic factor for progression of lymphoma and/or SS. Such patients may require treatment for both MALT lymphoma and SS. In SS patients with localized asymptomatic MALT lymphoma and low SS disease activity, a “watchful waiting” strategy seems justified. |
| Databáze: | OpenAIRE |
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