Neuropharmacologic Approaches to Restore the Brain’s Microenvironment

Autor: Santhi Gorantla, Yuanan Lu, Weizhe Li, Larisa Y. Poluektova, Howard E. Gendelman, Hsin-I Tong
Rok vydání: 2016
Předmět:
Zdroj: Journal of Neuroimmune Pharmacology. 11:484-494
ISSN: 1557-1904
1557-1890
DOI: 10.1007/s11481-016-9686-5
Popis: Maintaining the central nervous system microenvironment after injury, infection, and inflammatory and degenerative diseases is contingent upon adequate control of glial homeostatic functions. Disease is caused by microbial, environmental and endogenous factors that compromise ongoing nervous system function. The final result is neuronal dysfunction, dropout and nerve connection loss, and these underlie the pathobiology of Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, stroke, and bacterial, parasitic and viral infections. However, what promotes disease are homeostatic changes in the brain's microenvironment affected by innate glial immune pro-inflammatory and adaptive immune responses. These events disturb the brain's metabolic activities and communication abilities. How the process affects the brain's regulatory functions that can be harnessed for therapeutic gain is the subject at hand. Specific examples are provided that serve to attenuate inflammation and improve disease outcomes specifically for HIV-associated neurocognitive disorders.
Databáze: OpenAIRE
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