Risk factors and outcomes of cytomegalovirus viremia in pediatric hematopoietic stem cell transplantation patients
| Autor: | Meng-Yao Lu, Yung-Lin Yang, Shiann-Tarng Jou, Li-Min Huang, Hsuan-Yin Ma, Jhong-Lin Wu, Luan-Ying Chang, Hsiu-Hao Chang, Chun-Yi Lu, Jong-Min Chen, Ping-Ing Lee |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_treatment lcsh:QR1-502 Cytomegalovirus Hematopoietic stem cell transplantation Gastroenterology Pediatrics lcsh:Microbiology Hospitals University 0302 clinical medicine Immunology and Allergy Child Univariate analysis Incidence Incidence (epidemiology) virus diseases General Medicine Hospitals Pediatric Treatment Outcome Infectious Diseases surgical procedures operative Child Preschool 030220 oncology & carcinogenesis Cytomegalovirus Infections Female Microbiology (medical) medicine.medical_specialty Adolescent Taiwan Congenital cytomegalovirus infection Viremia Real-Time Polymerase Chain Reaction Sepsis Young Adult 03 medical and health sciences Internal medicine Immunology and Microbiology(all) medicine Humans Retrospective Studies General Immunology and Microbiology business.industry Infant Newborn Infant Odds ratio medicine.disease Transplant Recipients Transplantation Risk factors DNA Viral Immunology business 030215 immunology |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 50, Iss 3, Pp 307-313 (2017) |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2015.07.011 |
| Popis: | Background: Cytomegalovirus (CMV) is a major pathogen causing significant mortality and morbidity in immunocompromised hosts. It is important to find risk factors associated with CMV viremia and its outcome. Methods: We investigated the incidence, time of onset, risk factors for CMV viremia, and characteristics of CMV diseases in 57 pediatric patients receiving hematopoietic stem cell transplantation (HSCT). Between August 2011 and March 2014, cases of pediatric HSCT patients at the National Taiwan University Children's Hospital were reviewed. Viremia was identified by plasma CMV real-time polymerase chain reaction (RT-PCR) assay. Results: Eighteen (32%) of the 57 patients developed CMV viremia at a median of 23 days post-HSCT (range −3 to +721 days). Eighty-nine percent (16/18) of CMV viremia occurred within 100 days posttransplantation. Four patients finally had CMV diseases (1 with CMV colitis and 3 with CMV pneumonitis) and one patient died of CMV pneumonitis complicated with pulmonary hemorrhage and sepsis. Significant risk factors associated with CMV viremia via univariate analysis include older age (p = 0.03), leukemic patients [odds ratio (OR): 5.2, 95% confidence interval (CI): 1.52∼17.7, p = 0.008), allogeneic HSCT (OR: 14.57, 95% CI: 1.76∼120.5, p = 0.002), antithymoglobulin (ATG) use before transplantation (OR: 5.09, 95% CI: 1.52∼16.9, p = 0.007), graft-versus-host disease (GvHD) (OR: 10.1, 95% CI: 2.7∼38.7, p |
| Databáze: | OpenAIRE |
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