From the smallest to the largest subcellular plant pathogen: Citrus tristeza virus and its unique p23 protein
| Autor: | Pedro Moreno, Carmelo López, Susana Ruiz-Ruiz, Leandro Peña, José Guerri |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
p23-transgenic citrus Citrus Closterovirus CTV pathogenicity CTV resistance History 20th Century Virus-host interactions Plants Genetically Modified F60 Plant physiology and biochemistry History 21st Century p23 subcellular localization Infectious Diseases p23 protein Virology H20 Plant diseases Plant Diseases |
| Zdroj: | electronico ReDivia. Repositorio Digital del Instituto Valenciano de Investigaciones Agrarias instname |
| ISSN: | 1872-7492 |
| Popis: | Knowledge on diseases caused by Citrus tristeza virus (CTV) has greatly increased in last decades after their etiology was demonstrated in the past seventies. Professor Ricardo Flores substantially contributed to these advances in topics like: I) improvement of virus purification to obtain biologically active virions, II) sequencing mild CTV isolates for genetic comparisons with sequences of moderate or severe isolates and genetic engineering, III) analysis of genetic variation of both CTV genomic RNA ends and features of the highly variable 5′ end that allow accommodating this variation within a conserved secondary structure, IV) studies on the structure, subcellular localization and biological functions of the CTV-unique p23 protein, and v) potential use of p23 and other 3′ -proximal regions of the CTV genome to develop transgenic citrus resistant to the virus. Here we review his main achievements on these topics and how they contributed to deeper understanding of CTV biology and to new potential measures for disease control. |
| Databáze: | OpenAIRE |
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