Phosphoinositide 3-Kinases as Potential Targets for Thrombosis Prevention

Autor:	Natasha M. Setiabakti, Pia Larsson, Justin R. Hamilton
Rok vydání:	2022
Předmět:	Blood Platelets Organic Chemistry Thrombosis General Medicine Phosphatidylinositols Catalysis Computer Science Applications Inorganic Chemistry Phosphatidylinositol 3-Kinases Humans Protein Isoforms Physical and Theoretical Chemistry Molecular Biology Spectroscopy
Zdroj:	International journal of molecular sciences. 23(9)
ISSN:	1422-0067
Popis:	As integral parts of pathological arterial thrombi, platelets are the targets of pharmacological regimens designed to treat and prevent thrombosis. A detailed understanding of platelet biology and function is thus key to design treatments that prevent thrombotic cardiovascular disease without significant disruption of the haemostatic balance. Phosphoinositide 3-kinases (PI3Ks) are a group of lipid kinases critical to various aspects of platelet biology. There are eight PI3K isoforms, grouped into three classes. Our understanding of PI3K biology has recently progressed with the targeting of specific isoforms emerging as an attractive therapeutic strategy in various human diseases, including for thrombosis. This review will focus on the role of PI3K subtypes in platelet function and subsequent thrombus formation. Understanding the mechanisms by which platelet function is regulated by the various PI3Ks edges us closer toward targeting specific PI3K isoforms for anti-thrombotic therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1c8d6723fc725d54ea3b531981dfaa https://pubmed.ncbi.nlm.nih.gov/35563228 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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