New imaging markers for preconceptional and first-trimester utero-placental vascularization

Autor: Eric A.P. Steegers, Maria P.H. Koster, Graham J. Burton, Sten P. Willemsen, Annemarie G.M.G.J. Mulders, A. Frudiger, I. F. Reijnders, Eric Jauniaux, Régine P.M. Steegers-Theunissen, Anton H. J. Koning
Přispěvatelé: Obstetrics & Gynecology, Pathology, Epidemiology, Pediatrics
Rok vydání: 2018
Předmět:
Adult
medicine.medical_specialty
Placenta
Neovascularization
Physiologic
urologic and male genital diseases
Ultrasonography
Prenatal
03 medical and health sciences
0302 clinical medicine
Imaging
Three-Dimensional
Obstetrics and gynaecology
Pregnancy
Medicine
Humans
University medical
Placental Circulation
030212 general & internal medicine
health care economics and organizations
030219 obstetrics & reproductive medicine
Blood Volume
business.industry
Obstetrics
Uterus
Angiography
Virtual Reality
Obstetrics and Gynecology
Embryo
Mammalian
humanities
Placentation
First trimester
Pregnancy Trimester
First
Reproductive Medicine
In utero
Regional Blood Flow
Ultrasonography
Doppler
Pulsed
Ultrasound imaging
Feasibility Studies
Female
Preconception Care
business
Placental vascularization
Biomarkers
Developmental Biology
Zdroj: Placenta, 61, 96-102. W.B. Saunders
ISSN: 0143-4004
Popis: The availability of imaging makers of early placental circulation development is limited. This study aims to develop a feasible and reliable method to assess preconceptional and early first-trimester utero-placental vascular volumes using three-dimensional power Doppler (3D PD) ultrasound on two different Virtual Reality (VR) systems.3D PD ultrasound images of the uterine and placental vasculature were obtained in 35 women, either preconceptionally (n = 5), or during pregnancy at 7 (n = 10), 9 (n = 10) or 11 (n = 10) weeks of gestation. Preconceptional uterine vascular volume (UVV), first-trimester placental vascular volume (PVV) and embryonic vascular volume (EVV) were measured by two observers on two VR systems, i.e., a Barco I-Space and VR desktop. Intra- and inter-observer agreement and intersystem agreement were assessed by intra-class correlation coefficients (ICC) and absolute and relative differences.Uterine-, embryonic- and placental vascular volume measurements showed good to excellent intra- and inter-observer agreement and inter-system reproducibility with most ICC above 0.80 and relative differences of less than 20% preconceptionally and almost throughout the entire gestational age range. Inter-observer agreement of PVV at 11 weeks gestation was suboptimal (ICC 0.69, relative difference 50.1%).Preconceptional and first-trimester 3D PD ultrasound utero-placental and embryonic vascular volume measurements using VR are feasible and reliable. Longitudinal cohort studies with repeated measurements are needed to further validate this and assess their value as new imaging markers for placental vascular development and ultimately for the prediction of placenta-related pregnancy complications.
Databáze: OpenAIRE
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