An Antioxidant, Probucol, Induces Anti‐angiogenesis and Apoptosis in Athymic Nude Mouse Xenografted Human Head and Neck Squamous Carcinoma Cells
| Autor: | Goshi Nishimura, Hiromi Mizuno, Mamoru Tsukuda, Syunsuke Yanoma, Koji Kawakami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
medicine.medical_specialty Vascular smooth muscle Angiogenesis Probucol Mice Nude Neovascularization Physiologic Apoptosis Biology Article Antioxidants Mice Lipid oxidation Internal medicine medicine Anti‐oxidant Tumor Cells Cultured Animals Anticarcinogenic Agents Humans Mice Inbred BALB C Cell growth Cell Cycle Head and neck squamous cell carcinoma Immunohistochemistry Squamous carcinoma Endocrinology Oncology Epidermoid carcinoma Head and Neck Neoplasms biology.protein Cancer research Carcinoma Squamous Cell Female Drug Screening Assays Antitumor Anti‐angiogenesis Platelet-derived growth factor receptor Neoplasm Transplantation medicine.drug |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 1876-4673 0910-5050 |
| Popis: | Probucol is a very strong synthetic antioxidant that was been safely used for the treatment of hyperlipidemia in Japan since 1985. It has been reported that lipid oxidation products can alter growth factor production, which could influence smooth muscle cell proliferation. Oxidized low density lipoprotein can influence smooth muscle cell proliferation by enhancing the expression of platelet-derived growth factor (PDGF)-AA gene and PDGF receptor in vascular smooth muscle cell. Further, free radical reactions can cause irreversible alterations of genomic constituents during the initiation phase of carcinogenesis. Antioxidant is considered to protect lipids and low density lipoprotein (LDL) from oxidation, which potentially inhibits angiogenesis, and rapid removal of free radicals by antioxidants could have an anti-carcinogenic effect. In the present study, we investigated whether antioxidant treatment with probucol had an antitumor effect on KB cells, a human head and neck squamous carcinoma cell line. Probucol did not have any effect on KB cells in vitro, but probucol treatment of KB cells xenografts in mice had a significant antitumor effect through anti-angiogenic and apoptosis-inducing actions. These results support the idea that probucol is useful for preventing and/or treating cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text