Temporary and lasting cardiac effects of pre- and postnatal exposure to carbon monoxide
| Autor: | Kathleen E. Fanning, Michael S. Baylerian, David G. Penney |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Litter (animal)
Aging medicine.medical_specialty Time Factors Exponential regression Hematocrit Toxicology Hemoglobins Fetal Heart Animal science Pregnancy Internal medicine medicine Animals Maternal-Fetal Exchange Pharmacology Carbon Monoxide Fetus medicine.diagnostic_test Chemistry Body Weight Heart Organ Size medicine.disease Rats Endocrinology Animals Newborn Room air distribution Gestation Female Hemoglobin |
| Zdroj: | Toxicology and Applied Pharmacology. 53:271-278 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(80)90426-3 |
| Popis: | Pregnant female rats inhaled 200 ppm CO for the last 18 days of gestation, and a portion of their young inhaled 500 ppm CO for an additional 29 days after birth. Body weight (BW) and litter size of the CO-exposed newborn were significantly lower than those of unexposed controls. Heart weight (HW) of the exposed newborn was significantly larger than the controls, as was also HW BW ratio. Hemoglobin concentration, hematocrit, and red blood cell count were significantly lower in the exposed newborn than in controls In young rats exposed to CO both pre- and postnatally, HW BW ratio was more than twice as large as that of unexposed controls at 14, 21, and 29 days after birth (statistically significant), while in young rats exposed only as fetuses HW BW ratio was only slightly higher than in controls at the same time intervals. The remaining rats in all three groups were allowed to mature to 105 days of age in room air, at which time they too were sacrificed. HW BW ratio of the pre- and postnatally exposed rats was significantly elevated above the same parameters for the controls and rats exposed to CO as fetuses only. The HW BW ratio of the latter two groups did not differ significantly from one another. Analysis of HW data using multiple exponential regression equations relating HW to BW, showed HW of the rats exposed to CO both pre- and postnatally to be 22% larger than predicted. The results suggest that fetal cardiomegaly induced by CO is entirely reversible, while neonatal exposure produces long-standing changes in HW. |
| Databáze: | OpenAIRE |
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