Case-control study of the immune status of humans infected with zoonotic gorilla simian foamy viruses
| Autor: | Richard Njouom, Florence Buseyne, Thomas Montange, Antoine Gessain, Edouard Betsem, Chanceline Bilounga Ndongo |
|---|---|
| Přispěvatelé: | Epidémiologie et Physiopathologie des Virus Oncogènes (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Yaoundé I, Ministère de la Santé Publique [Yaoundé, Cameroun], Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), This work was supported by the Institut Pasteur in Paris, France, the Programme Transversal de Recherche from the Institut Pasteur [PTR#437] and the Agence Nationale de la Recherche [grant ANR-10-LABX-62-IBEID and REEMFOAMY project, ANR 15-CE-15-0008-01], We thank the participants of the study. We greatly appreciate the Institut de Recherche pour le Développement (IRD) for their support for the field work. This text has been verified by a native English speaker., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-15-CE15-0008,REEMFOAMY,L'infection humaine par les virus foamy simiens zoonotiques : rôle des facteurs virologiques et immunologiques dans la restrcition de l'emergence virale(2015), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut Pasteur [Paris], Ministère de la Santé Publique [Cameroun], Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Yaoundé I [Yaoundé], We thank the participants of the study. We greatly appreciate the Institut de Recherche pour le Développement (IRD) for their support for the field work. This text has been verified by a native English speaker, ANR-10-LABX-62-IBEID,IBEID,Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases'(2010) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Primates 0301 basic medicine foamy virus Programmed Cell Death 1 Receptor 030106 microbiology CD8-Positive T-Lymphocytes Simian immune activation 03 medical and health sciences Immune system Simian foamy virus Immunity [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Zoonoses T lymphocyte Animals Humans Immunology and Allergy Medicine emergence Receptor Immune Checkpoint Inhibitors Aged [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases biology business.industry Monocyte Case-control study Middle Aged zoonosis biology.organism_classification retrovirus Chronic infection 030104 developmental biology Infectious Diseases medicine.anatomical_structure Gene Expression Regulation [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology Case-Control Studies Immunology monocyte [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology check-point inhibitor business CD8 Retroviridae Infections |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, 2020, pp.jiz660. ⟨10.1093/infdis/jiz660⟩ Journal of Infectious Diseases, Oxford University Press (OUP), 2020, pp.jiz660. ⟨10.1093/infdis/jiz660⟩ |
| ISSN: | 0022-1899 1537-6613 |
| Popis: | BackgroundZoonotic simian foamy viruses (SFVs) establish persistent infections in humans, for whom the long-term consequences for health are poorly described. In this study, we aimed to characterize blood-cell phenotypes and plasma biomarkers associated with gorilla SFV infection in humans.MethodsWe used a case-control design to compare 15 Cameroonian hunters infected with gorilla SFV (cases) to 15 controls matched for age and ethnicity. A flow cytometry-based phenotypic study and quantification of plasma immune biomarkers were carried out on blood samples from all participants. Wilcoxon signed-rank tests were used to compare cases and controls.ResultsCases had a significantly higher percentage of CD8 T lymphocytes than controls (median, 17.6% vs 13.7%; P = .03) but similar levels of B, natural killer, and CD4 T lymphocytes. Cases also had a lower proportion of recent CD4 thymic emigrants (10.9% vs 18.6%, P = .05), a higher proportion of programmed death receptor 1 (PD-1) expressing memory CD4 T lymphocytes (31.7% vs 24.7%, P = .01), and higher plasma levels of the soluble CD163 scavenger receptor (0.84 vs .59 µg/mL, P = .003) than controls.ConclusionsWe show, for the first time, that chronic infection with SFV is associated with T lymphocyte differentiation and monocyte activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|