Anti-TNF antibody treatment reduces mortality in experimental dengue virus infection
Autor: | Peter Petzelbauer, George Ignatyev, Alena Atrasheuskaya, Terry M. Fredeking |
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Rok vydání: | 2003 |
Předmět: |
Microbiology (medical)
Male Immunology Dengue virus medicine.disease_cause Antibodies Viral Microbiology Virus Dengue fever Dengue Mice Immune system medicine Immunology and Allergy Animals Humans Mice Inbred BALB C biology Tumor Necrosis Factor-alpha Mortality rate Immunization Passive General Medicine Dengue Virus biology.organism_classification medicine.disease Interleukin 10 Flavivirus Disease Models Animal Infectious Diseases Tumor necrosis factor alpha |
Zdroj: | FEMS immunology and medical microbiology. 35(1) |
ISSN: | 0928-8244 |
Popis: | Here we describe a lethal mouse model infected with dengue virus type 2 with several similarities to human DEN-2 infection. Clinically animals demonstrated anemia, thrombocytopenia, pre-terminal paralysis and shock. The most impressive changes were seen with tumor necrosis factor (TNF)-alpha, which abruptly and steeply increased 24 h before the exitus (mean at day 6). Serum levels of IL-1beta, IL-6, IL-10, IL-1 receptor antagonist and soluble TNF receptor I continuously increased during the time of infection. A 100% mortality rate was noted in that group of animals. Treating animals with anti-TNF-alpha serum reduced mortality rate down to 40% (P0.05). Our model supports the view that activation of innate immune response is at least partially responsible for mortality in DEN-2 infection, and in line with this concept, anti-TNF treatment significantly reduces mortality rates. |
Databáze: | OpenAIRE |
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