New onset epilepsy in the elderly: clinical, radiological and electroencephalographic features and treatment responses
| Autor: | Erum M. Shariff, Fahd A Al-Khamis |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Pediatrics medicine.medical_specialty Saudi Arabia Comorbidity 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Ictal Stroke Aged Retrospective Studies Aged 80 and over Epilepsy business.industry Incidence (epidemiology) Medical record Electroencephalography Retrospective cohort study Middle Aged medicine.disease Psychiatry and Mental health Treatment Outcome 030104 developmental biology Cohort Etiology Anticonvulsants Female Original Article Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurosciences |
| ISSN: | 1658-3183 |
| DOI: | 10.17712/nsj.2017.2.20160527 |
| Popis: | Objective: To evaluate new onset epilepsy characteristics, etiology, radiological and electroencephalographic features and to document treatment response in the elderly. Method: This was a retrospective study carried out in King Fahd Medical City, Riyadh, Kingdom of Saudi Arabia, from 2010 to 2013. Medical records were searched to recruit patients. Hundred and nineteen patients were enrolled who fulfill the inclusion criteria. Clinical data with respect to seizure semiology, etiology, electroencephalographic findings, radiological findings, co-morbidities, and anti-epileptic drug (AED) therapy were assessed. Results: Cerebrovascular disease was the most common etiology, followed by occult cerebrovascular disease (oCVD). Focal onset seizures were the most common clinical presentation in this group of cohort. Electroencephalogram (EEG) showed generalized slowing in majority of patients (45.5%), with 21.8% interictal epileptiform activity. Patients required lower doses of AEDs to control seizures, gain better seizure control. Common co-morbidities were hypertension and diabetes mellitus. Conclusion: Patients presenting with LOE, should have search for any other cerebrovascular risk factors. Further research is needed to determine the prevalence of oCVD in LOE, and to investigate whether addressing cerebrovascular risk factors in this cohort of patients can reduce the incidence of stroke. |
| Databáze: | OpenAIRE |
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