Miconazole mucoadhesive buccal tablet in high-dose therapy with autologous stem cell transplantation (HDT/ASCT)-induced mucositis
| Autor: | S. François, J. F. Hamel, Norbert Ifrah, Aline Tanguy-Schmidt, F. Moal, Mélanie Mercier, Corentin Orvain, Mathilde Hunault-Berger, M. P. Moles-Moreau, E. Parot-Schinkel |
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| Přispěvatelé: | Service des maladies du sang [CHU Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Bernardo, Elizabeth |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Mucositis medicine.medical_specialty Antifungal Agents Adolescent Miconazole Analgesic [SDV.CAN]Life Sciences [q-bio]/Cancer Transplantation Autologous Gastroenterology Young Adult Autologous stem-cell transplantation [SDV.CAN] Life Sciences [q-bio]/Cancer Amphotericin B Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Aged Stomatitis business.industry Hematopoietic Stem Cell Transplantation Induction chemotherapy Induction Chemotherapy Buccal administration Middle Aged medicine.disease 3. Good health Surgery Transplantation Treatment Outcome Oncology Female Multiple Myeloma business Tablets medicine.drug |
| Zdroj: | Supportive Care in Cancer Supportive Care in Cancer, Springer Verlag (Germany), 2015, 23 (2), pp.359-364. ⟨10.1007/s00520-014-2365-2⟩ Supportive Care in Cancer, 2015, 23 (2), pp.359-364. ⟨10.1007/s00520-014-2365-2⟩ |
| ISSN: | 0941-4355 1433-7339 |
| DOI: | 10.1007/s00520-014-2365-2⟩ |
| Popis: | International audience; Oral mucositis is a major cause of morbidity in high-dose therapy/autologous stem cell transplantation (HDT/ASCT), where microbial colonization has an important pathological implication. In this study, we evaluated the impact of miconazole mucoadhesive buccal tablet (MBT) on mucositis-related complications. During two consecutive 34-month periods, patients treated with HDT/ASCT in our hematology department received either miconazole MBT (60 patients) or conventional oral amphotericin B suspensions three times a day (44 patients) in order to prevent or decrease chemotherapy-induced mucositis. The use of miconazole MBT is associated with less infectious complications as indicated by shorter antibiotic use (7.8 vs. 12.3 days; p < 0.0001), shorter intravenous antifungal use (1.4 vs. 3.6 days; p = 0.02), and a trend towards less yeast contamination in stool samples. Less patients required any analgesic drugs during hospitalization in the miconazole MBT group (18 vs. 7 %; p = 0.09). Indirect indicators of chemotherapy-induced mucositis (duration of hospitalization, morphine use) were in favor of miconazole MBT in patients with multiple myeloma (MM) but not for those with lymphoma. This study suggests that miconazole MBT provides a valid alternative to oral amphotericin B suspensions in regards to mucositis-related complications. A prospective and randomized study is warranted to establish the definite role of miconazole MBT. |
| Databáze: | OpenAIRE |
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