Infralimbic and prelimbic prefrontal cortex activation is necessary to the enhancement of aversive memory extinction promoted by reactivation
| Autor: | Pâmela Billig Mello-Carpes, Karine Ramires Lima, Liane da Silva de Vargas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Infralimbic cortex Ventromedial prefrontal cortex Prefrontal Cortex Inhibitory postsynaptic potential Extinction Psychological chemistry.chemical_compound Memory Avoidance Learning medicine Animals natural sciences GABA-A Receptor Agonists Rats Wistar Prefrontal cortex Molecular Biology Muscimol General Neuroscience social sciences Extinction (psychology) musculoskeletal system humanities Rats medicine.anatomical_structure chemistry Facilitation Stress disorders Neurology (clinical) Neuroscience geographic locations Developmental Biology |
| Zdroj: | Brain Research. 1770:147630 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2021.147630 |
| Popis: | Memory extinction has been used in behavioral therapy to treat post-traumatic stress disorders. It was demonstrated that memory reactivation before extinction could facilitate this process. However, the mechanisms involved are still unclear. Here, we investigated the participation of two regions of the ventromedial prefrontal cortex (vmPFC), the infralimbic (IL) and prelimbic (PL), in the memory reactivation modulatory effect of fear extinction. We confirmed that the reactivation facilitates the fear extinction in an inhibitory aversive task; however, when the muscimol (a GABAergic agonist) is infused in IL or PL vmPFC after reactivation, extinction's facilitation was not observed. These findings support the idea that the reactivation can modulate the fear extinction process, facilitating it, and that this effect requires the activation of both IL and PL regions of vmPFC. |
| Databáze: | OpenAIRE |
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