Should PRECISE-DAPT be included for long-term prognostic stratification of diabetic patients with NSTEACS?
| Autor: | V. Ramos, Pilar Zuazola, José Ramón González Juanatey, Diego Iglesias Álvarez, Carla Eugenia Cacho Antonio, Alberto Cordero, Federico García‑Rodeja Arias, Charigan Abou Jokh Casas, Belén Cid Álvarez, David Escribano, José María García Acuña, Rosa Agra Bermejo, Teba González Ferrero, Pedro Rigueiro Veloso, Óscar Otero García, Jesús Martinón Martínez, Francisco Gude Sampedro, Belén Álvarez Álvarez, Pablo Tasende Rey |
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| Rok vydání: | 2021 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Endocrinology Diabetes and Metabolism Risk Assessment Prognostic stratification Percutaneous Coronary Intervention Endocrinology Risk Factors Internal medicine Diabetes mellitus Diabetes Mellitus Internal Medicine medicine Humans In patient Acute Coronary Syndrome Aged Retrospective Studies Cardiovascular mortality Framingham Risk Score business.industry General Medicine Middle Aged Prognosis medicine.disease Invasive coronary angiography Female business Platelet Aggregation Inhibitors Mace |
| Zdroj: | Acta Diabetologica. 59:163-170 |
| ISSN: | 1432-5233 0940-5429 |
| Popis: | There are insufficient data regarding risk scores validation in patients with diabetes mellitus and non-ST elevation acute coronary syndrome (NSTEACS). We performed a diabetes mellitus-specific analysis of cardiovascular outcomes after NSTEACS. We tested the predictive power of the Global Registry of Acute Coronary Events (GRACE) and PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent Dual Anti-Platelet Therapy (PRECISE-DAPT) scores.This work is a retrospective analysis that included 7,415 consecutive NSTEACS patients from two Spanish Universitarian hospitals between the years 2003 and 2017. The area under the ROC curve among with and without diabetes mellitus patients was calculated, to evaluate the predictive power of both scores. RESULTS: Among the study participants, 2124 patients (28.0%) were diabetic. The median follow-up was 54,3 months (IQR 24,7-80,0 months). Diabetic patients were more women (30.5% vs. 25.7%) and older (70.0 ± 10.8 vs. 65.3 ± 13.2 years old); they had higher GRACE (146 ± 36 vs. 137 ± 36), PRECISE-DAPT (15 ± 7 vs. 18 ± 9) at admission. Early invasive coronary angiography (≤ 24 h after admission) was performed more frequently in non-diabetic. We tested the predictive power of the GRACE and PRECISE-DAPT risk scores among diabetic and non-diabetic. PRECISE-DAPT risk score showed a good predictive power for all-cause mortality, cardiovascular mortality and MACE in diabetic admitted with NSTEACS, without differences compared to non-diabetic.PRECISE-DAPT risk score has an appropriate predictive power in diabetic patients admitted with NSTEACS compared to non-diabetic NSTEACS. However, GRACE would be predictive worse in diabetic during long-term follow-up in a large contemporary registry. |
| Databáze: | OpenAIRE |
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