1-Acyltriazoles as antiinflammatory agents
Autor: | B. Richard Vogt, Robert C. Millonig, Thomas P. Kissick, Douglas M. Palmer, Ligaya M. Simpkins, Peter C. Wade |
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Rok vydání: | 1982 |
Předmět: |
chemistry.chemical_classification
Male Stereochemistry Substituent Anti-Inflammatory Agents Ibuprofen Triazoles Arthritis Experimental chemistry.chemical_compound Mice Structure-Activity Relationship chemistry Group (periodic table) Drug Discovery Arthus Reaction Molecular Medicine Animals Edema Selection (genetic algorithm) Alkyl Acyl group |
Zdroj: | Journal of medicinal chemistry. 25(3) |
ISSN: | 0022-2623 |
Popis: | Certain 1-acyl-3-phenyl-5-alkyltriazoles were synthesized and evaluated for antiinflammatory activity using the mouse active Arthus (MAA) reaction as the test system. Modification of the acyl group, 4-phenyl substituent, and alkyl group led to the selection of the most active member of this series, 1-acetyl-3-(4-chlorophenyl)-5-methyl-1,2,4-triazole (3c), for further evaluation as a novel nonacidic antiinflammatory agent. |
Databáze: | OpenAIRE |
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