1-Acyltriazoles as antiinflammatory agents

Autor: B. Richard Vogt, Robert C. Millonig, Thomas P. Kissick, Douglas M. Palmer, Ligaya M. Simpkins, Peter C. Wade
Rok vydání: 1982
Předmět:
Zdroj: Journal of medicinal chemistry. 25(3)
ISSN: 0022-2623
Popis: Certain 1-acyl-3-phenyl-5-alkyltriazoles were synthesized and evaluated for antiinflammatory activity using the mouse active Arthus (MAA) reaction as the test system. Modification of the acyl group, 4-phenyl substituent, and alkyl group led to the selection of the most active member of this series, 1-acetyl-3-(4-chlorophenyl)-5-methyl-1,2,4-triazole (3c), for further evaluation as a novel nonacidic antiinflammatory agent.
Databáze: OpenAIRE