Growth, short stature, and the use of growth hormone: considerations for the practicing pediatrician
| Autor: | I. David Schwartz, Jerome A. Grunt |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Turner Syndrome Growth Hypopituitarism Growth hormone Pediatrics Short stature Reference Values Internal medicine Turner syndrome medicine Humans Bovine somatotropin Child Growth Substances Physician's Role Growth Disorders business.industry Growth hormone–releasing hormone medicine.disease Endocrinology Gonadal Steroid Hormones Growth Hormone Pediatrics Perinatology and Child Health Kidney Failure Chronic Female medicine.symptom business Hormone |
| Zdroj: | Current Problems in Pediatrics. 22:390-412 |
| ISSN: | 0045-9380 |
| Popis: | Introduction Over the past 35 years knowledge has increased remarkably regarding the mechanisms controlling growth; the structure, function, and synthesis of the hormones involved in the growth system; and the clinical applications of this information. The presence of a pituitary growth-promoting factor was first demonstrated in the rat by Evans and Long, as reported in 1921.l It took 23 years before Li and coworkers’ extracted and characterized the function of bovine growth hormone (GH) and 7 more years before Raben and Westermeyer3 developed methods of extracting human pituitaries and produced an active human GH (hGH). By 1956 Li and Papkoff were able to purify hGH4 and during the next several years a number of investigators began to study the effects of hGH in children, evaluating metabolic changes5 and growth.‘j, 7 Before 1964 most of the hGH used for biochemical and physiologic study, as well as for evaluating clinical responses, was obtained from Drs. Raben and Wilhelmi, who traded GH for pituitaries with many of the pediatric endocrinologists throughout the United States. The process became more organized with the establishment of the National Pituitary |
| Databáze: | OpenAIRE |
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