Combination chemotherapy with carboplatin, capecitabine and epirubicin (ECarboX) as second- or third-line treatment in patients with relapsed ovarian cancer: a phase I/II trial
| Autor: | Martin Gore, Christian Rothermundt, C. Keyzor, T Ahmad, I Gibbens, R. Hubner, T Habeshaw, Stan B. Kaye |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty endocrine system diseases Maximum Tolerated Dose medicine.medical_treatment Administration Oral Deoxycytidine Carboplatin Capecitabine chemistry.chemical_compound Internal medicine Antineoplastic Combined Chemotherapy Protocols Clinical Studies Medicine Humans Infusions Intravenous Aged Cisplatin Ovarian Neoplasms relapse Chemotherapy business.industry capecitabine Combination chemotherapy Middle Aged medicine.disease epirubicin Surgery Treatment Outcome ovarian cancer chemistry Area Under Curve Toxicity Injections Intravenous Female Neoplasm Recurrence Local business Ovarian cancer medicine.drug Epirubicin |
| Zdroj: | British Journal of Cancer |
| ISSN: | 0007-0920 |
| Popis: | Platinum-based combination chemotherapy has been proven to be superior to single-agent platinum in the treatment of relapsed ovarian cancer after a treatment-free interval of more than 6 months. A response rate of 41% was previously reported by our group using a combination of epirubicin, cisplatin and 5-FU in patients who relapsed within 12 months, we therefore assessed a similar, but more convenient combination of epirubicin, carboplatin and capecitabine in this phase-I/II trial. In total, 18 patients with recurrent epithelial ovarian carcinoma, who had not received more than two lines of chemotherapy and the treatment-free interval exceeded 6 months were treated with carboplatin AUC5, epirubicin 50 mg m(-2) and capecitabine at several dose levels on continuous 21 day cycles and 14 of 21 day cycles. Patients were assessed for toxicity and by CT and CA-125 for response. The overall response rate was 61.1%, with three complete and eight partial responses. Grade 3/4 haematological toxicity was seen in 10 out of 18 patients and caused dose reductions and treatment delays. The combination of epirubicin, carboplatin and capecitabine showed good activity but caused excessive toxicity. A phase-II trial using carboplatin and capecitabine is underway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|