The comparative metabolism of [14C-vinyl]dichlorvos in animals and man
| Autor: | E. C. Hoadley, D. H. Hutson |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Chromatography Gas Time Factors Vinyl Compounds Chromatography Paper Health Toxicology and Mutagenesis Administration Oral Mice Inbred Strains Urine Toxicology Excretion Feces Mice chemistry.chemical_compound Biotransformation Cricetinae Dichlorvos Animals Humans Ingestion Carbon Isotopes Chromatography Air Respiration Hippuric acid General Medicine Metabolism Carbon Dioxide Rats chemistry Female Glucuronide |
| Zdroj: | Archiv f�r Toxikologie. 30:9-18 |
| ISSN: | 1432-0738 0340-5761 |
| Popis: | The routes of excretion and retention of radioactivity following the ingestion of [1-14C-vinyl]dichlorvos by mice and hamsters have been determined. The excretion of radioactivity in urine and exhaled air of man has also been measured. The data have been compared with those for rats. The results indicate that metabolism is rapid in the four species. Dealkylation to desmethyldichlorvos is a minor route of biotransformation, except in the mouse, where desmethyldichlorvos constitutes at least 18.5 % of the administered radioactivity. Hydrolytic metabolism of dichlorvos occurs in all species and leads presumably to dichloroacetaldehyde which is further metabolized by (i) reduction to dichloroethanol and excretion in the urine as the glucuronide and (ii) dechlorination followed by incorporation of the carbon atoms into endogenous biosyntheses and excretion as [14C]carbon dioxide and [14C]hippuric acid in the urine. Dichloroethanol can be detected inβ-glucuronidase-treated urine after exposure of a human subject to high air concentrations (38 μg/l) of non-radioactive dichlorvos. This may form the basis of a method of monitoring the exposure of humans to high concentrations of dichlorvos. |
| Databáze: | OpenAIRE |
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