New efficient approach for the synthesis of 2-alkyl(aryl) substituted 4H-pyrido[1,2-a]pyrimidin-4-ones
| Autor: | Cleber A. Cechinel, Nilo Zanatta, Michelle B. Costa, Isadora R. Rodrigues, Marcos A. P. Martins, Helio G. Bonacorso, Arci Dirceu Wastowski, Fernando J. Righi |
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| Zdroj: | ResearcherID |
| Popis: | A new, efficient and easy route for the preparation of a series of 2-alkyl(aryl) substituted 4-oxo-4H-pyrido-[1,2-a]pyrimidines, where alkyl = CH3; aryl = C6H5, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-CH3C6H4, 4-OCH3C6H4, 4-NO2C6H4 in 45–80 % yield from the reaction of β-alkoxyvinyl trichloromethyl ketones with 2-aminopyridine under mild conditions, is then reported. |
| Databáze: | OpenAIRE |
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