Case-control study between extrapleural pneumonectomy and radical pleurectomy/decortication for pathological N2 malignant pleural mesothelioma☆
Autor: | John G. Edwards, Antonio E. Martin-Ucar, Apostolos Nakas, David A. Waller |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male Mesothelioma Pulmonary and Respiratory Medicine Extrapleural Pneumonectomy medicine.medical_specialty Adolescent Pleural Neoplasms medicine.medical_treatment Population Kaplan-Meier Estimate Mediastinoscopy Pleural disease medicine Adjuvant therapy Humans Postoperative Period Radical surgery Pneumonectomy education Aged Retrospective Studies education.field_of_study medicine.diagnostic_test business.industry Age Factors General Medicine Length of Stay Middle Aged Decortication medicine.disease Combined Modality Therapy Surgery Treatment Outcome Case-Control Studies Pleura Female Cardiology and Cardiovascular Medicine business Pleurectomy |
Zdroj: | European Journal of Cardio-Thoracic Surgery. 31:765-770 |
ISSN: | 1010-7940 |
Popis: | Objective: To compare the outcomes of extrapleural pneumonectomy (EPP) and radical pleurectomy/decortication (P/D) for N2 malignant pleuralmesothelioma(MM).Patientsandmethods:Inaretrospective case-controlstudyweanalysedtheresultsofthe57 patients[49maleand8 female, median age 59 (range 14—70) years] who underwent radical surgery for MM found to have pathological N2 disease over a 7-year-period. EPP was performed on 45 and P/D on 12 patients. Prognostic factors, postoperative course, pathological data and postoperative survival were analysed. Results: Those in the P/D group were significantly older (median age 62 vs 58 years, p = 0.03) than in the EPP group. There was no difference in postoperative hospital stay (p = 0.1) nor T stage (p = 0.7) between the groups. There were no significant differences in the proportion of patients undergoing some adjuvant therapy in each group (p = 0.2). Mean survival from diagnosis was 15 months in the EPP group and 16 months for those who underwent P/D (p = 0.4). Conclusions: Preservation of the lung during radical surgery for N2 MM does not compromise survival even in an older group population. We therefore now have ceased to perform EPP in cases of N2 disease and we make every effort to accurately stage patients with mediastinoscopy to identify them. # 2007 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved. |
Databáze: | OpenAIRE |
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