Soluble fiber inulin consumption limits alterations of the gut microbiota and hepatic fatty acid metabolism caused by high-fat diet
| Autor: | Mayssa Albouery, Benoit Chassaing, Marie-Agnès Bringer, Alexis Bretin, Stéphane Grégoire, Niyazi Acar, Ségolène Gambert, Alain M. Bron, Lucy Martine, Bénédicte Buteau |
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| Přispěvatelé: | Julien, Sabine, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Georgia State University, University System of Georgia (USG), Laboratoire de biochimie médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de biochimie médicale (CHU Dijon) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Dietary Fiber Male 0301 basic medicine Gut flora Mice chemistry.chemical_compound RNA Ribosomal 16S Food science Diet Fat-Restricted 2. Zero hunger chemistry.chemical_classification Nutrition and Dietetics biology inulin food and beverages 3. Good health high-fat diet Fatty Acids Unsaturated Soluble fiber Composition (visual arts) lipids (amino acids peptides and proteins) lcsh:Nutrition. Foods and food supply Polyunsaturated fatty acid fiber Inulin lcsh:TX341-641 Diet High-Fat liver fatty acids Article metabolic syndrome 03 medical and health sciences lipid medicine microbiota Animals Triglycerides 030109 nutrition & dietetics Fatty acid metabolism Cholesterol HDL [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Cholesterol LDL Metabolism Lipid Metabolism biology.organism_classification medicine.disease Dietary Fats [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Gastrointestinal Microbiome Mice Inbred C57BL [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition 030104 developmental biology chemistry Metabolic syndrome [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Food Science |
| Zdroj: | Nutrients Nutrients, 2021, 13 (3), pp.1037. ⟨10.3390/nu13031037⟩ Volume 13 Issue 3 Nutrients, MDPI, 2021, 13 (3), pp.1037. ⟨10.3390/nu13031037⟩ Nutrients, Vol 13, Iss 1037, p 1037 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13031037⟩ |
| Popis: | International audience; Diet shapes the gut microbiota which impacts hepatic lipid metabolism. Modifications in liver fat content are associated with metabolic disorders. We investigated the extent of dietary fat and fiber-induced alterations in the composition of gut microbiota and hepatic fatty acids (FAs). Mice were fed a purified low-fat diet (LFD) or high-fat diet (HFD) containing non-soluble fiber cellulose or soluble fiber inulin. HFD induced hepatic decreases in the amounts of C14:0, C16:1n-7, C18:1n-7 and increases in the amounts of C17:0, C20:0, C16:1n-9, C22:5n-3, C20:2n-6, C20:3n-6, and C22:4n-6. When incorporated in a LFD, inulin poorly affected the profile of FAs. However, when incorporated in a HFD, it (i) specifically led to an increase in the amounts of hepatic C18:0, C22:0, total polyunsaturated FAs (PUFAs), total n-6 PUFAs, C18:3n-3, and C18:2n-6, (ii) exacerbated the HFD-induced increase in the amount of C17:0, and (iii) prevented the HFD-induced increases in C16:1n-9 and C20:3n-6. Importantly, the expression/activity of some elongases and desaturases, as well as the gut microbiota composition, were impacted by the dietary fat and fiber content. To conclude, inulin modulated gut microbiota and hepatic fatty acid composition, and further investigations will determine whether a causal relationship exists between these two parameters. |
| Databáze: | OpenAIRE |
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