Preparation and mineralization of a biocompatible double network hydrogel
| Autor: | Quanzhu Yang, Xueqing Zou, Liqiong Liao, Fangfang Song |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Toughness
Scaffold Materials science Simulated body fluid Double network Biomedical Engineering Biophysics Biocompatible Materials Bioengineering macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Mineralization (biology) Cell Line Polyethylene Glycols Biomaterials chemistry.chemical_compound Tissue engineering Biomimetic Materials Materials Testing Animals Regeneration Composite material Tissue Engineering Tissue Scaffolds technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology Rats 0104 chemical sciences Durapatite Polyglutamic Acid Chemical engineering chemistry Self-healing hydrogels 0210 nano-technology Ethylene glycol |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 28:431-443 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1080/09205063.2017.1279044 |
| Popis: | Double network (DN) hydrogels have shown favorable toughness and strength and been harnessed as scaffolding materials in tissue engineering, particularly, mineralized DN hydrogels may be potential scaffolds in bone tissue engineering. In this paper, DN hydrogels were fabricated from poly(ethylene glycol) diacrylate (PEGDA) and methacrylated poly(γ-glutamic acid) (mPGA). This DN hydrogel not only showed excellent mechanical properties but also good cytocompatibility as evidenced by the characterizations in terms of swelling ratio, mechanical strength/modulus, and cytotoxicity. Further, the DN hydrogels were subjected to mineralization in simulated body fluid, during which hydroxyapatite or analogues formed within the DN hydrogels; the DN hydrogels may be potentially harnessed as bone tissue engineering scaffold. |
| Databáze: | OpenAIRE |
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