Formation of Antibody in the Newborn Mouse: Study of T-Cell-Independent Antibody Response
| Autor: | Donald E. Mosier, E. A. Goldings, William E. Paul, Irwin Scher, N. M. Zaldivar, James J. Mond |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Lipopolysaccharides
T-Lymphocytes Lymphocyte T cell Brucella abortus Mice Inbred Strains chemical and pharmacologic phenomena Spleen Cell Maturation Mice Mice Inbred AKR Immune system Antigen medicine Animals Immunology and Allergy Antigens Pan-T antigens Antigens Bacterial B-Lymphocytes Mice Inbred BALB C biology Age Factors Antibodies Bacterial Infectious Diseases medicine.anatomical_structure Animals Newborn Antibody Formation Immunology biology.protein Antibody |
| Zdroj: | Journal of Infectious Diseases. 136:S14-S19 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/136.supplement.s14 |
| Popis: | The ontogeny of immune responsiveness, as assayed by antibody formation in vitro, of mouse spleen lymphocytes to thymus-independent antigens is reviewed. Responsiveness to trinitrophenyl (TNP)-lipopolysaccharide and TNP-Brucella abortus appear soon after birth and one to two weeks before TNP-Ficoll or capsular polysaccharide of Streptococcus pneumoniae (SSS-III) elicits significant antibody formation. This hierarchy of responsiveness to antigens is also apparent in the CBA/N mutant mouse strain, which has a bone marrow-derived (B-) cell maturation arrest and fails to respond to either TNP-Ficoll or SSS-III. These findings are interpreted to suggest sequential maturation of different populations or lines of B-lymphocytes, each of which can respond to a defined class of thymus-independent antigens. The implication for vaccine use in humans is that a late-appearing subclass of B-cells may be required for adequate immune responses to polysaccharide antigens. |
| Databáze: | OpenAIRE |
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