Dynamic Recovery from Depression Enables Rate Encoding in Inhibitory Synapses
| Autor: | Shiyong Huang, Alfredo Kirkwood, Morgan S. Bridi, Sangyep Shin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
02 engineering and technology Molecular neuroscience Optogenetics Article Synapse 03 medical and health sciences Cellular neuroscience Mathematical Biosciences medicine lcsh:Science Multidisciplinary Sensory stimulation therapy Chemistry musculoskeletal neural and ocular physiology fungi Biological Sciences 021001 nanoscience & nanotechnology 030104 developmental biology medicine.anatomical_structure Visual cortex nervous system Cellular Neuroscience lcsh:Q Pyramidal cell Molecular Neuroscience 0210 nano-technology Neural coding Neuroscience |
| Zdroj: | iScience iScience, Vol 23, Iss 3, Pp-(2020) |
| ISSN: | 2589-0042 |
| Popis: | Summary Parvalbumin-expressing fast-spiking interneurons (PV-INs) control network firing and the gain of cortical response to sensory stimulation. Crucial for these functions, PV-INs can sustain high-frequency firing with no accommodation. However, PV-INs also exhibit short-term depression (STD) during sustained activation, largely due to the depletion of synaptic resources (vesicles). In most synapses the rate of replenishment of depleted vesicles is constant, determining an inverse relationship between depression levels and the activation rate, which theoretically, severely limits rate-coding capabilities. We examined STD of the PV-IN to pyramidal cell synapse in the mouse visual cortex and found that in these synapses the recovery from depression is not constant but increases linearly with the frequency of use. By combining modeling, dynamic clamp, and optogenetics, we demonstrated that this recovery enables PV-INs to reduce pyramidal cell firing in a linear manner, which theoretically is crucial for controlling the gain of cortical visual responses. Graphical Abstract Highlights • Recovery rate from depression in inhibitory synapses from PV-INs is use dependent • Dynamic recovery from depression enables rate coding in inhibitory inputs • PV-IN synapses reduce pyramidal firing in a frequency-dependent manner Biological Sciences; Neuroscience; Molecular Neuroscience; Cellular Neuroscience; Mathematical Biosciences |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|