Impact of Intensive Lifestyle Intervention on Neural Food Cue Reactivity: Action for Health in Diabetes Brain Ancillary Study
| Autor: | R. Nick Bryan, Samantha E Williams, Regina L. Leckie, Rena R. Wing, Lisa Desiderio, Thomas A. Wadden, Kathryn Demos McDermott, Mark A. Espeland, Rebecca Neiberg, Kirk I. Erickson, Lucy H Falconbridge, John M. Jakicic, Miguel Alonso-Alonso |
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| Rok vydání: | 2019 |
| Předmět: |
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medicine.medical_specialty Randomization Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Type 2 diabetes Overweight Article law.invention 03 medical and health sciences 0302 clinical medicine Endocrinology Randomized controlled trial Behavior Therapy law Weight loss Internal medicine Diabetes mellitus medicine Humans 030212 general & internal medicine Life Style Nutrition and Dietetics business.industry Brain Cognition Middle Aged medicine.disease Magnetic Resonance Imaging Obesity Diabetes Mellitus Type 2 Female Cues medicine.symptom business Food Analysis |
| Zdroj: | Obesity (Silver Spring) |
| ISSN: | 1930-739X 1930-7381 |
| DOI: | 10.1002/oby.22496 |
| Popis: | OBJECTIVE The Action for Health in Diabetes (Look AHEAD) research study was a randomized trial comparing the effects of an intensive lifestyle intervention (ILI) versus a diabetes support and education (DSE) control group in adults with type 2 diabetes and overweight or obesity. Functional magnetic resonance imaging was used to determine whether neural food cue reactivity differed for these groups 10 years after randomization. METHODS A total of 232 participants (ILI, n = 125, 72% female; DSE, n = 107, 64% female) were recruited at three of the Look AHEAD sites for functional magnetic resonance imaging. Neural response to high-calorie foods compared with nonfoods was assessed in DSE versus ILI. Exploratory correlations were conducted within ILI to identify regions in which activity was associated with degree of weight loss. RESULTS Voxel-wise whole-brain comparisons revealed greater reward-processing activity in left caudate for DSE compared with ILI and greater activity in attention- and visual-processing regions for ILI than DSE (P |
| Databáze: | OpenAIRE |
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