cagA gene and protein status among Iranian Helicobacter pylori strains
| Autor: | Hamid Reza Vaziri, Mahmoud Eshagh Hosseini, L Zamaninia, Nazanin Mohajerani, Mohammad Ali Mohagheghi, A Oghalaei, Maryam Esmaeili, Yeganeh Talebkhan, Marjan Mohammadi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Peptic Ulcer Adolescent Physiology Spirillaceae Iran digestive system Serology Helicobacter Infections Cohort Studies Bacterial Proteins Predictive Value of Tests Seroepidemiologic Studies Stomach Neoplasms Genotype CagA Humans Typing Child Genotyping Aged Aged 80 and over Antigens Bacterial biology Helicobacter pylori Gastroenterology Middle Aged bacterial infections and mycoses biology.organism_classification Antibodies Bacterial digestive system diseases Case-Control Studies Immunology biology.protein Female Antibody Polymorphism Restriction Fragment Length |
| Zdroj: | Digestive diseases and sciences. 53(4) |
| ISSN: | 0163-2116 |
| Popis: | The wide geographic genetic diversity of Helicobacter pylori (Hp) and, in particular, the varying prevalence of cagA in different countries has been documented repeatedly. This study was designed to determine the frequency of cagA in Iranian Hp strains by means of genotyping and assessment of host antibodies. Helicobacter pylori strains from 235 patients, including 174 non-ulcer dyspepsia, 25 peptic ulcer and 36 gastric cancer patients, were studied. The frequencies of the 5', middle and 3' terminal regions of the cagA gene were 90.6, 57.6, 89%, respectively, with no correlation to the clinical outcomes. Antibodies against the CagA protein were present in 90.7% of patients. Multiple biopsy sampling in 97 cases revealed multiple infection in 16.5% of the patients. Sequencing of the seven variants of the 3' end of the cagA gene revealed no clustering and the distribution of the Iranian strains among those of other countries. Our results from the genotyping and serology analyses confirm that the majority of Iranian Hp strains are cagA-positive. |
| Databáze: | OpenAIRE |
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