Methylene blue exerts rapid neuroprotective effects on lipopolysaccharide-induced behavioral deficits in mice
| Autor: | Wenjing Li, Xi Yin, Shuang-cheng Li, Yuan Gao, Hai-Shui Shi, Omar Israel Velez de-la-Paz, Juan Shao, Shuo Yin, Xinhao Wang |
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| Rok vydání: | 2018 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Lipopolysaccharide medicine.medical_treatment Neuroprotection 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Mice 0302 clinical medicine Internal medicine medicine Animals Saline 030304 developmental biology 0303 health sciences Depressive Disorder Memory Disorders Behavior Animal business.industry Neurogenesis Tail suspension test Heme oxygenase Methylene Blue Disease Models Animal Endocrinology Neuroprotective Agents chemistry Antidepressant business 030217 neurology & neurosurgery Behavioural despair test |
| Zdroj: | Behavioural brain research. 356 |
| ISSN: | 1872-7549 |
| Popis: | Depression is a recurrent neuropsychiatric disorder accompanied with other behavioral deficits, including memory impairment. A few studies have shown that methylene blue (MB) could promote cortical neurogenesis and exert neuroprotective effects on various brain diseases, including bipolar disorder. However, the potential antidepressant effects of MB have not been fully investigated. The present study was designed to investigate the effects of MB pretreatment on behavioral deficits and the underlying mechanisms in a lipopolysaccharide (LPS)-induced depression mouse model. Mice were given saline (5 mL/kg) or MB (5, 20 mg/kg) intraperitoneally (i.p.) 30 min prior to lipopolysaccharide (LPS, 800 μg/kg, i.p.) or the following behavioral tests. Thereafter, serum heme oxygenase 1(HO1) were determined by ELISA. The results showed that LPS significantly induced body weight loss and behavioral deficits that included increased floating time in the forced swimming test, increased immobility time in the tail suspension test, decreased sucrose preference in the sucrose preference test, and memory impairment in the novel object recognition (all p |
| Databáze: | OpenAIRE |
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