High expression of cyclic nucleotide phosphodiesterase 7B mRNA predicts poor prognosis in mantle cell lymphoma
| Autor: | Jianyong Li, Lei Fan, Cheng Fang, Zhi-Jian Zou, Ji Xu, Hua-Jie Dong, Li Wang, Wei Xu, Run Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Gene isoform Cancer Research Poor prognosis Mrna expression Lymphoma Mantle-Cell Biology Disease-Free Survival Gene Expression Regulation Enzymologic Bone Marrow Predictive Value of Tests immune system diseases hemic and lymphatic diseases medicine Humans Clinical significance RNA Messenger RNA Neoplasm Aged Retrospective Studies Messenger RNA Cyclic Nucleotide Phosphodiesterases Type 7 Cyclic nucleotide phosphodiesterase Hematology Middle Aged medicine.disease Molecular biology Neoplasm Proteins Gene Expression Regulation Neoplastic Survival Rate medicine.anatomical_structure Oncology Female Mantle cell lymphoma Bone marrow |
| Zdroj: | Leukemia Research. 37:536-540 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2013.02.006 |
| Popis: | In order to determine the relationship between expression of cyclic nucleotide phosphodiesterase isoform 7B (PDE7B) and mantle cell lymphoma (MCL) progression, PDE7B mRNA expression was measured by qRT-PCR in 21 untreated MCL patients with bone marrow involvement and 20 healthy donors. The expression level of PDE7B was markedly higher in MCL patients compared with normal controls ( P = 0.001), and the higher level of PDE7B expression was associated with unfavorable cytogenetic characteristics in MCL. It was showed that higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL, which possess important clinical significance. |
| Databáze: | OpenAIRE |
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