Splenic diffuse red pulp lymphoma has a distinct pattern of somatic mutations amongst B-cell malignancies

Autor: Françoise Berger, Pascale Felman, Sandrine Hayette, Martine Ffrench, Laurent Jallades, Bertrand Coiffier, Evelyne Callet-Bauchu, Kaddour Chabane, Aurélie Verney, Sophie Gazzo, Gilles Salles, Alexandra Traverse-Glehen, Lucile Baseggio
Přispěvatelé: Laboratoire d'anatomie et de cytopathologie - Centre hospitalier Lyon Sud, Hospices Civils de Lyon ( HCL ), Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Cancer Research
Pathology
Lymphoma
diagnosis
DNA Mutational Analysis
medicine.disease_cause
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
0302 clinical medicine
Immunophenotyping
Lymphocytes
In Situ Hybridization
Fluorescence
Aged
80 and over
Mutation
Hematology
Middle Aged
Immunohistochemistry
3. Good health
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Red pulp
Female
France
IGHV@
medicine.medical_specialty
Lymphoma
B-Cell
Patients
Cells
[SDV.CAN]Life Sciences [q-bio]/Cancer
Splenic Neoplasm
Biology
03 medical and health sciences
Antigens
CD
blood
Biomarkers
Tumor
medicine
Humans
Genetic Predisposition to Disease
B cell
Aged
Neoplasm Staging
Retrospective Studies
Chromosome Aberrations
Splenic Neoplasms
medicine.disease
Lymph Nodes
Splenic Lymphoma
030215 immunology
Zdroj: Leukemia & lymphoma
Leukemia & lymphoma, Taylor & Francis, 2017, 58, pp.666-675. 〈10.1080/10428194.2016.1196813〉
Leukemia & lymphoma, Taylor & Francis, 2017, 58, pp.666-675. ⟨10.1080/10428194.2016.1196813⟩
Europe PubMed Central
ISSN: 1042-8194
1029-2403
Popis: International audience; Splenic Diffuse Red Pulp Lymphoma (SDRPL) has been recently introduced as a provisional entity but differential diagnosis with other splenic lymphomas is needed to be clarified since the therapeutic approaches are distinct. Recently described recurrent mutations or CD180 expression appear useful for differential diagnosis. We completed our previous description in a larger cohort including 53 patients selected on the presence of characteristic villous cells in peripheral blood (PB) and a specific immunophenotype. Immunoglobulin heavy variable (IGHV), BRAF, MYD88, and NOTCH2 mutations were determined and CD180 and BRAF expressions were assessed. Most cases (79%) were IGHV mutated with an overrepresentation of IGHV3-23 (19%) and IGHV4-34 (21%). MYD88 L265P and NOTCH2 mutations were observed in one case each, whereas no BRAF V600E mutation or expression was found. All cases demonstrated a high CD180 expression. Those results strengthen the concept that SDRPL does emerge as a new lymphoma entity distinct from the other splenic lymphomas with circulating lymphocytes
Databáze: OpenAIRE
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