Splenic diffuse red pulp lymphoma has a distinct pattern of somatic mutations amongst B-cell malignancies
Autor: | Françoise Berger, Pascale Felman, Sandrine Hayette, Martine Ffrench, Laurent Jallades, Bertrand Coiffier, Evelyne Callet-Bauchu, Kaddour Chabane, Aurélie Verney, Sophie Gazzo, Gilles Salles, Alexandra Traverse-Glehen, Lucile Baseggio |
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Přispěvatelé: | Laboratoire d'anatomie et de cytopathologie - Centre hospitalier Lyon Sud, Hospices Civils de Lyon ( HCL ), Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ) -Hospices Civils de Lyon ( HCL ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Hospices Civils de Lyon (HCL), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Cancer Research Pathology Lymphoma diagnosis DNA Mutational Analysis medicine.disease_cause [ SDV.CAN ] Life Sciences [q-bio]/Cancer 0302 clinical medicine Immunophenotyping Lymphocytes In Situ Hybridization Fluorescence Aged 80 and over Mutation Hematology Middle Aged Immunohistochemistry 3. Good health medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Red pulp Female France IGHV@ medicine.medical_specialty Lymphoma B-Cell Patients Cells [SDV.CAN]Life Sciences [q-bio]/Cancer Splenic Neoplasm Biology 03 medical and health sciences Antigens CD blood Biomarkers Tumor medicine Humans Genetic Predisposition to Disease B cell Aged Neoplasm Staging Retrospective Studies Chromosome Aberrations Splenic Neoplasms medicine.disease Lymph Nodes Splenic Lymphoma 030215 immunology |
Zdroj: | Leukemia & lymphoma Leukemia & lymphoma, Taylor & Francis, 2017, 58, pp.666-675. 〈10.1080/10428194.2016.1196813〉 Leukemia & lymphoma, Taylor & Francis, 2017, 58, pp.666-675. ⟨10.1080/10428194.2016.1196813⟩ Europe PubMed Central |
ISSN: | 1042-8194 1029-2403 |
Popis: | International audience; Splenic Diffuse Red Pulp Lymphoma (SDRPL) has been recently introduced as a provisional entity but differential diagnosis with other splenic lymphomas is needed to be clarified since the therapeutic approaches are distinct. Recently described recurrent mutations or CD180 expression appear useful for differential diagnosis. We completed our previous description in a larger cohort including 53 patients selected on the presence of characteristic villous cells in peripheral blood (PB) and a specific immunophenotype. Immunoglobulin heavy variable (IGHV), BRAF, MYD88, and NOTCH2 mutations were determined and CD180 and BRAF expressions were assessed. Most cases (79%) were IGHV mutated with an overrepresentation of IGHV3-23 (19%) and IGHV4-34 (21%). MYD88 L265P and NOTCH2 mutations were observed in one case each, whereas no BRAF V600E mutation or expression was found. All cases demonstrated a high CD180 expression. Those results strengthen the concept that SDRPL does emerge as a new lymphoma entity distinct from the other splenic lymphomas with circulating lymphocytes |
Databáze: | OpenAIRE |
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