Functional connectivity of the Precuneus reflects effectiveness of visual restitution training in chronic hemianopia
| Autor: | Hinke N. Halbertsma, Albert V. van den Berg, Koen V. Haak, Douwe P. Bergsma, Joris A. Elshout, Frans W Cornelissen, David G. Norris |
|---|---|
| Přispěvatelé: | Perceptual and Cognitive Neuroscience (PCN) |
| Rok vydání: | 2020 |
| Předmět: |
Male
genetic structures Precuneus Audiology lcsh:RC346-429 Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] VRT visual restitution training Resting-state Functional connectivity Visual restitution training Hemianopia 0302 clinical medicine VRSN visual resting-state networks Parietal Lobe Neural Pathways Image Processing Computer-Assisted Attention Selective attention RS resting-state VF visual field Brain Mapping 05 social sciences Brain 220 Statistical Imaging Neuroscience Regular Article Spatial attention Middle Aged Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Magnetic Resonance Imaging Visual field medicine.anatomical_structure Neurology Visual discrimination Visual Perception lcsh:R858-859.7 Female Psychology Adult medicine.medical_specialty Cognitive Neuroscience Rest FC functional connectivity lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology 150 000 MR Techniques in Brain Function 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center HFA Humphreys field analyser medicine VFD visual field defect Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging WM white matter lcsh:Neurology. Diseases of the nervous system Aged Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] Resting state fMRI Eye movement GM grey matter eye diseases Restitution fMRI functional MRI FWE family-wise error Hemianopsia GAS goal attainment score Neurology (clinical) Nerve Net 030217 neurology & neurosurgery |
| Zdroj: | Neuroimage. Clinical, 27 NeuroImage: Clinical, Vol 27, Iss, Pp 102292-(2020) NeuroImage : Clinical NeuroImage. Clinical, 27:102292. ELSEVIER SCI LTD |
| ISSN: | 2213-1582 |
| Popis: | Highlights • We found a visual restitution training effect modulated by attention in hemianopia. • When at rest, Precuneus and Occipital Pole Network are functionally connected. • The strength of this connection prior to training was positively related to training effect. • Precuneus may play a role in visual field improvements by modulating attention. • Our finding may help identifying patients most likely to benefit from training. Visual field defects in chronic hemianopia can improve through visual restitution training, yet not all patients benefit equally from this long and exhaustive procedure. Here, we asked if resting-state functional connectivity prior to visual restitution could predict training success. In two training sessions of eight weeks each, 20 patients with chronic hemianopia performed a visual discrimination task by directing spatial selective attention towards stimuli presented in either hemifield, while suppressing eye movements. We examined two effects: a sensitivity change in the attended (trained) minus the unattended (control) hemifield (i.e., a training-specific improvement), and an overall improvement (i.e., a total change in sensitivity after both sessions). We then identified five visual resting-state networks and evaluated their functional connectivity in relation to both training effects. We found that the functional connectivity strength between the anterior Precuneus and the Occipital Pole Network was positively related to the attention modulated (i.e., training-specific) improvement. No such relationship was found for the overall improvement or for the other visual networks of interest. Our finding suggests that the anterior Precuneus plays a role in attention-modulated visual field improvements. The resting-state functional connectivity between the anterior Precuneus and the Occipital Pole Network may thus serve as an imaging-based biomarker that quantifies a patient's potential capacity to direct spatial attention. This may help to identify hemianopia patients that are most likely to benefit from visual restitution training. |
| Databáze: | OpenAIRE |
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