Prevalence of Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome
| Autor: | Clara Salas, Pablo de la Cuadra, Fernando Dominguez, Isabel Zegri-Reiriz, F. Javier de Haro-del Moral, Esther Gonzalez-Lopez, Isabel Krsnik, Pablo García-Pavía, Aresio Plaza |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors Occupational risk Pharmaceutical Science 030204 cardiovascular system & hematology Left ventricular hypertrophy Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Genetics Prevalence Medicine Humans In patient Carpal tunnel syndrome Genetics (clinical) Aged Aged 80 and over Ventricular Remodeling business.industry Amyloidosis Middle Aged medicine.disease Carpal Tunnel Syndrome nervous system diseases 030104 developmental biology Cardiac amyloidosis Cohort Cardiology Molecular Medicine Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business Attr amyloidosis |
| Zdroj: | Journal of cardiovascular translational research. 12(6) |
| ISSN: | 1937-5395 |
| Popis: | Carpal tunnel syndrome (CTS) is a common finding among patients with cardiac amyloidosis. We sought to determine the prevalence of cardiac amyloidosis in patients who had undergone CTS surgery. From 2005 to 2014, 308 patients ≥ 60 years underwent CTS surgery. Of these, 233 (76%) agreed to participate in the study and 101 (73 ± 8 years; 68% females) showed left ventricular hypertrophy (LVH) ≥ 12 mm and underwent additional studies to diagnose AL and ATTR amyloidosis. Based on complementary studies, three patients were diagnosed with cardiac amyloidosis (two wild-type ATTR and one AL). The three patients showed bilateral CTS with no occupational risk factors. Prevalence of cardiac amyloidosis in the overall cohort was only 1.2% (3/233), but among patients with LVH and bilateral CTS, the prevalence was 5.5% (3/55) and 13.6% (3/22) if cases with an occupational risk factor were excluded. Cardiac amyloidosis should be excluded in the presence of bilateral CTS and particularly if an occupational risk factor is absent. |
| Databáze: | OpenAIRE |
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