Impact of Pore Size and Surface Chemistry of Porous Silicon Particles and Structure of Phospholipids on Their Interactions
| Autor: | Xiaocao Wan, Jarno Salonen, Dongfei Liu, Tapio Kotiaho, Hélder A. Santos, Jouni Hirvonen, Katriina Lipponen, Peng Quan, Risto Kostiainen, Hongbo Zhang, Ermei Mäkilä |
|---|---|
| Přispěvatelé: | Drug Research Program, Preclinical Drug Formulation and Analysis group, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Helsinki Institute of Life Science HiLIFE, Risto Kostiainen / Principal Investigator, Jouni Hirvonen / Principal Investigator, Tapio Kotiaho / Principal Investigator, Department of Chemistry, Nanomedicines and Biomedical Engineering |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Letter
Fabrication STRATEGIES 116 Chemical sciences Biomedical Engineering ELECTROSTATIC INTERACTION FABRICATION Nanoparticle surface chemistry 02 engineering and technology 010402 general chemistry Porous silicon 01 natural sciences LIPIDOMICS Biomaterials chemistry.chemical_compound Adsorption NANOPARTICLES pore size DRUG-DELIVERY Porosity COMBINATION ta317 phospholipids RELEASE Carbonization Chemistry BILAYER FORMATION MICROPARTICLES Biomaterial 021001 nanoscience & nanotechnology 0104 chemical sciences porous silicon Chemical engineering 317 Pharmacy adsorption 216 Materials engineering Triethoxysilane 0210 nano-technology |
| Zdroj: | ACS Biomaterials Science & Engineering |
| Popis: | By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed TOPSi, AnnTOPSi; (3-aminopropyl) triethoxysilane functionalized thermally carbonized PSi, APTES-TCPSi; and thermally hydrocarbonized PSi, THCPSi] on their surface interactions with different phospholipids. All of the four phospholipids were similarly adsorbed by the surface of PSi particles, except for TOPSi. Among four PSi particles, TOPSi with hydrophilic surface and smaller pore size showed the weakest adsorption toward phosphatidylcholines. By increasing the pore size from roughly 12.5 to 18.0 nm (TOPSi vs AnnTOPSi), the quantity of phosphatidylcholines adsorbed by TOPSi was enhanced to the same level of hydrophilic APTES-TCPSi and hydrophobic THCPSi. The 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) exhibited the highest release ratio of phospholipids from all four PSi particles, and phosphatidylserine (DPPS) showed the lowest release ratio of phospholipids from PSi particles, except for TOPSi, which adsorbed less phospholipids due to the small pore size. There is consistency in the release extent of phospholipids from PSi particles and the isosteric heat of adsorption. Overall, our study demonstrates the importance of pore size and surface chemistry of PSi particles as well as the structure of phospholipids on their interactions. The obtained information can be employed to guide the selection of PSi particles and phospholipids to fabricate highly ordered structures, for example, protocells, or biomimetic reactors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|