Antifungal susceptibility profiles of 1698 yeast reference strains revealing potential emerging human pathogens
| Autor: | Marie Desnos-Ollivier, Françoise Dromer, Vincent Robert, Dorothée Raoux-Barbot, Marizeth Groenewald |
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| Přispěvatelé: | Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire (CNRMA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centraalbureau voor Schimmelcultures Fungal Biodiversity Centre (CBS-KNAW), Thanks to Damien Hoinard (NRCMA) and Wendy Epping (CBS) for technical help. Thanks to Dea Garcia-Hermoso and Stéphane Bretagne for proofreading. Thanks to Jack Edwards and Marc Orbach for their helpful information about use of antifungal in agricultures., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Basidiomycetes
Azoles Antifungal Agents Opportunistic pathogens Antifungal drug lcsh:Medicine Human pathogen MESH: Drug Design Antimicrobial resistance Reference Values Candida albicans MESH: Phylogeny lcsh:Science Phylogeny Fungal pathogens [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology MESH: Microbial Sensitivity Tests 0303 health sciences Multidisciplinary Ascomycota biology Temperature MESH: Reference Values MESH: Temperature 3. Good health Infectious Diseases Phenotype Medicine Echinocandins Research Article MESH: Fungi Drugs and Devices Mycology Microbial Sensitivity Tests MESH: Ascomycota MESH: Phenotype Microbiology MESH: Drug Resistance Fungal 03 medical and health sciences MESH: Mycoses Antibiotic resistance Species Specificity Drug Resistance Fungal In vivo Humans MESH: Species Specificity Biology 030304 developmental biology Antifungals MESH: Humans 030306 microbiology Basidiomycota lcsh:R Fungi MESH: Antifungal Agents biology.organism_classification Ascomycetes Yeast MESH: Basidiomycota Mycoses Drug Design lcsh:Q |
| Zdroj: | PLoS ONE, Vol 7, Iss 3, p e32278 (2012) PLoS One, 7(3):e32278. Public Library of Science PLoS ONE PLoS ONE, Public Library of Science, 2012, 7 (3), pp.e32278. ⟨10.1371/journal.pone.0032278⟩ PLoS ONE, 2012, 7 (3), pp.e32278. ⟨10.1371/journal.pone.0032278⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; New molecular identification techniques and the increased number of patients with various immune defects or underlying conditions lead to the emergence and/or the description of novel species of human and animal fungal opportunistic pathogens. Antifungal susceptibility provides important information for ecological, epidemiological and therapeutic issues. The aim of this study was to assess the potential risk of the various species based on their antifungal drug resistance, keeping in mind the methodological limitations. Antifungal susceptibility profiles to the five classes of antifungal drugs (polyens, azoles, echinocandins, allylamines and antimetabolites) were determined for 1698 yeast reference strains belonging to 992 species (634 Ascomycetes and 358 Basidiomycetes). Interestingly, geometric mean minimum inhibitory concentrations (MICs) of all antifungal drugs tested were significantly higher for Basidiomycetes compared to Ascomycetes (p |
| Databáze: | OpenAIRE |
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