Risk of Developing Specific AIDS‐Defining Illnesses in Patients Coinfected with HIV and Hepatitis C Virus With or Without Liver Cirrhosis
| Autor: | D'ARMINIO MONFORTE, A, COZZI LEPRI, A, Castagna, A, Antinori, A, DE LUCA, A, Mussini, C, Caputo, Sl, Arlotti, M, Magnani, G, Pellizzer, G, Lichtner, Miriam, Maggiolo, F, Puoti, M, Vullo, Vincenzo, AND ICONA FOUNDATION STUDY GROUP |
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| Přispěvatelé: | D'Arminio Monforte A, Cozzi-Lepri A, Castagna A, Antinori A, De Luca A, Mussini C, Caputo SL, Arlotti M, Magnani G, Pellizzer G, Maggiolo F, Puoti M, Icona Foundation Study Group: [.., Verucchi G, Chiodo F, ], Monforte A., D'Arminio, Cozzi Lepri, Alessandro, Castagna, Antonella, Antinori, Andrea, De Luca, Andrea, Mussini, Cristina, Lo Caputo, Sergio, Arlotti, Massimo, Magnani, Giacomo, Pellizzer, Gianpietro, Maggiolo, Franco, Puoti, Massimo |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Liver Cirrhosis Male Microbiology (medical) HIV AIDS HCV medicine.medical_specialty Cirrhosis Adolescent Hepatitis C virus Hepacivirus medicine.disease_cause Cohort Studies Young Adult Acquired immunodeficiency syndrome (AIDS) Risk Factors Internal medicine Humans Medicine Risk factor CIRRHOSIS Aged Aged 80 and over COINFECTION HIV/HCV Acquired Immunodeficiency Syndrome AIDS-Related Opportunistic Infections business.industry Incidence virus diseases Bacterial Infections Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Infectious Diseases Italy Mycoses Immunology Disease Progression Coinfection Female Viral disease Serostatus business |
| Zdroj: | Clinical Infectious Diseases. 49:612-622 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/603557 |
| Popis: | Background There are few data concerning the risk of specific opportunistic diseases in patients with and without hepatitis C virus (HCV) infection. We evaluated the correlation between the occurrence of different AIDS-defining illnesses (ADIs) and chronic HCV infection or HCV-related liver cirrhosis in a large Italian cohort of human immunodeficiency virus (HIV)-infected subjects. Methods Subjects were stratified into 2 groups: patients without HCV coinfection and with persistently normal aminotransferase levels and patients with HCV coinfection. The patients with HCV coinfection were stratified according to the diagnosis of liver cirrhosis. The incidences of new ADIs were calculated as the number of events per 1000 person-years of follow-up. The rates in the 2 groups were compared using a Poisson regression model adjusted for potential confounders. Results We observed a total of 496 ADIs among 5397 patients with 25,105 person-years of follow-up (50% tested positive for HCV). HCV coinfection was associated with increased risk of developing an ADI (adjusted relative rate [ARR], 2.61; 95% confidence interval [CI], 1.88-3.61), specifically bacterial infection (ARR, 3.15; 95% CI, 1.76-5.67), HIV-related disease (ARR, 2.68; 95% CI, 1.03-6.97), and mycotic disease (ARR, 3.87; 95% CI, 2.28-6.59) but not non-Hodgkin lymphoma (ARR, 0.88; 95% CI, 0.22-3.48). The rate of mycotic infection, bacterial infection, toxoplasmosis, and HIV-related ADI among patients with cirrhosis were significantly higher than that among HIV-monoinfected patients, and the risk was greater than that estimated for HCV antibody-positive patients without cirrhosis. Conclusions HIV-related bacterial and mycotic infections are strongly associated with positive HCV serostatus and HCV-related cirrhosis. Clinicians should take into account these data when making decisions on initiation of antiretroviral therapy for HCV-coinfected individuals. |
| Databáze: | OpenAIRE |
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