Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading

Autor:	A. D. Ulanova, S. P. Belova, V K Zhalimov, Boris Shenkman, Elmira I Yakupova, Ivan M. Vikhlyantsev, Tatiana L. Nemirovskaya, Yu. V. Gritsyna, A. G. Bobylev, Ekaterina P. Mochalova
Rok vydání:	2019
Předmět:	0301 basic medicine Male medicine.medical_specialty animal structures Histone Deacetylase 1 Hindlimb Phenylenediamines General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Atrophy Internal medicine Gene expression medicine Animals Protein Isoforms Connectin Rats Wistar Muscle Skeletal Soleus muscle M soleus biology Chemistry General Medicine Organ Size Hindlimb Suspension musculoskeletal system medicine.disease HDAC1 Rats Histone Deacetylase Inhibitors Muscular Atrophy 030104 developmental biology Endocrinology Gene Expression Regulation Benzamides biology.protein Titin 030217 neurology & neurosurgery Signal Transduction
Zdroj:	Bulletin of experimental biology and medicine. 169(4)
ISSN:	1573-8221
Popis:	We studied the effect of histone deacetylase 1 (HDAC1) inhibition on titin content and expression of TTN gene in rat m. soleus after 3-day gravitational unloading. Male Wistar rats weighing 210±10 g were randomly divided into 3 groups: control, 3-day hindlimb suspension, and 3-day hindlimb suspension and injection of HDAC1 inhibitor CI-994 (1 mg/kg/day). In hindlimb-suspended rats, the muscle weight/animal body weight ratio was reduced by 13.8% (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefa0206929cb784cf0698fa8523f7d6 https://pubmed.ncbi.nlm.nih.gov/32889570 Zobrazit plný text záznamu Full text from SpringerLink