Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones Using an Imidazole-Based Chiral PNN Tridentate Ligand
| Autor: | Huacui Hou, Ze Wang, Jiachen Chen, Weihui Zhong, Xiao Yi, Sanfei Nian, Fei Ling, Dingguo Song |
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| Rok vydání: | 2019 |
| Předmět: |
Tridentate ligand
010405 organic chemistry Organic Chemistry Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element Manganese 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Imidazole Physical and Theoretical Chemistry |
| Zdroj: | Organic Letters. 21:3937-3941 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.9b01056 |
| Popis: | A series of Mn(I) catalysts containing imidazole-based chiral PNN tridentate ligands with controllable "side arm" groups have been established, enabling the asymmetrical hydrogenation of unsymmetrical benzophenones with outstanding activity (up to 13 000 TON) and excellent enantioselectivity (up to99% ee). This protocol uses K |
| Databáze: | OpenAIRE |
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