Flow-mediated dilation is associated with cardiovascular events in non-valvular atrial fibrillation patients
| Autor: | Pasquale Pignatelli, Francesco Violi, Daniele Pastori, Ludovica Perri, Lorenzo Loffredo |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment flow mediated diolation Non valvular atrial fibrillation Stent Flow mediated dilation Atrial fibrillation medicine.disease Revascularization endothelial dysfunction atrial fibrillation myocardial infarction medicine.anatomical_structure Internal medicine Cardiology Medicine cardiovascular diseases Myocardial infarction Endothelial dysfunction Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | International Journal of Cardiology. 179:139-143 |
| ISSN: | 0167-5273 |
| Popis: | Background Atrial fibrillation is associated with multiple atherosclerotic risk factors and predisposes to cardiovascular events (CVE). Endothelial dysfunction is associated with atherosclerosis and independently predicts CVE. The aim of the study was to evaluate the association between endothelial dysfunction, as assessed by flow-mediated dilation (FMD), and CVE in AF patients. Methods We prospectively measured FMD in 514 non-valvular AF patients on anticoagulant treatment with vitamin K antagonists. Patients were followed-up for a mean time of 23.5months. The main composite outcome of the study was the occurrence of stroke/TIA, myocardial infarction, urgent revascularization and cardiovascular death. Results Median value of FMD was 4.6% [IQR 1.46–8.00]. A CVE occurred in 44 patients (8.56%):non-fatal myocardial infarction (MI) in 7, fatal MI in 2, stent/coronary artery by-pass graft (CABG) in 10, ischemic non-fatal stroke in 10, fatal stroke in 3, transient ischemic attack (TIA) in 1, and cardiovascular death in 11 patients. Patients who experienced a CVE showed significantly reduced FMD compared to those who did not (3.06% [IQR 0.00–6.00] vs 4.67% [IQR 1.58–8.22], p=0.027). During a mean follow-up of 23.5months, the rate of CVE was significantly higher in subjects with FMD below median ( Conclusions In AF patients low FMD is associated with increased risk of CVE suggesting that impaired artery dilatation predisposes to atherosclerotic complications. |
| Databáze: | OpenAIRE |
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