E. coli Lipopolysaccharide: acute oral toxicity study in mice
| Autor: | Gabrielle Carlson, D.J. Klocke, Tom Davis, Bryan Delaney, Marc S. Harper, Carol Carpenter |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Lipopolysaccharides
Male Pathology medicine.medical_specialty Lipopolysaccharide Ratón Physiology Administration Oral Biology Toxicology medicine.disease_cause Oral gavage chemistry.chemical_compound Mice Oral administration medicine Escherichia coli Toxicity Tests Acute Animals Oral toxicity Mice Inbred ICR Dose-Response Relationship Drug Toxin Body Weight General Medicine chemistry Toxicity bacteria Female Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 49(8) |
| ISSN: | 1873-6351 |
| Popis: | A single dose of endotoxin (lipopolysaccharide) from a common laboratory cloning and expression strain ( Escherichia coli BL21[DE3]) was administered to groups of male and female CD-1 mice ( n = 5/group) at doses up to 1,000,000 endotoxin units (EU) per mouse by oral gavage. The mice were observed for mortality, body weight effects, and clinical signs for 14 days after which they were sacrificed for gross organ necropsy. All mice survived until the scheduled sacrifice, no clinical signs of toxicity were observed, no test substance-related body weight losses occurred and no gross lesions were present at necropsy. Under the conditions of this study, oral administration of E. coli BL21(DE3) endotoxin to mice at a dose of up to 1,000,000 EU/mouse produced no evidence of toxicity. |
| Databáze: | OpenAIRE |
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