Ischemia/Reperfusion Injury in Flow-through Venous Flaps
| Autor: | Semra Gezer, Atay Atabey, Güldal Kirkali, Ali Barutçu, Haluk Vayvada, Adnan Menderes, Can Karaca |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Ischemia Hemodynamics Protein oxidation Surgical Flaps Lipid peroxidation Necrosis chemistry.chemical_compound medicine Animals Survival rate Free-radical theory of aging Lagomorpha biology business.industry medicine.disease biology.organism_classification eye diseases Surgery chemistry Reperfusion Injury Anesthesia Lipid Peroxidation Rabbits business Reperfusion injury |
| Zdroj: | Annals of Plastic Surgery. 40:612-616 |
| ISSN: | 0148-7043 |
| DOI: | 10.1097/00000637-199806000-00007 |
| Popis: | The effects of ischemia/reperfusion (IIR) injury in flow-through venous flaps were evaluated in rabbits. The rates of flap survival and the levels of lipid peroxidation, protein oxidation, and sulfhydryl groups were compared between flow-through venous flaps, conventional flaps after an IIR period (experimental groups), and flow-through venous flaps without being subjected to IIR injury (control groups) in 20 animals. On the seventh day after the onset of reperfusion, 3 of 10 flow-through venous flaps (30%) and 6 of 10 arteriovenous flaps (60%) survived in the experimental groups. Flow-through venous flaps showed a decreased survival rate compared with control and conventional flaps (p < 0.05). Tissue lipid peroxide levels were found to be higher in venous flaps during reperfusion after secondary ischemia (p < 0.05), Tissue protein oxidation and total sulfhydryl groups levels did not show any difference among groups. This study suggests that more free radical damage occurs in flow-through venous flaps during IIR injury. |
| Databáze: | OpenAIRE |
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