Randomized pilot study on probiotic effects on recurrent candidiasis in oral lichen planus patients
| Autor: | Camilla Kragelund, M K Keller |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Limosilactobacillus reuteri Male medicine.medical_specialty Pain Pilot Projects Placebo Gastroenterology Severity of Illness Index law.invention 03 medical and health sciences Probiotic 0302 clinical medicine Randomized controlled trial Double-Blind Method law Statistical significance Internal medicine Secondary Prevention Medicine Probiotic bacteria Humans General Dentistry Aged Pain Measurement business.industry Probiotics Candidiasis Administration Buccal 030206 dentistry Middle Aged medicine.disease stomatognathic diseases 030104 developmental biology Carriage Otorhinolaryngology Carrier State Oral lichen planus Female business Lozenge Lichen Planus Oral |
| Zdroj: | Oral diseases. 24(6) |
| ISSN: | 1601-0825 |
| Popis: | Some patients with oral lichen planus (OLP) experience recurrent oral candidiasis(OC). Probiotic bacteria have shown to reduce the oral Candida count in vivo. Objective To study whether probiotic intervention reduces recurrent OC in patients with OLP. Material and methods Twenty-two patients with symptomatic OLP were enrolled in the double-blinded, randomized, placebo-controlled intervention study. Lozenges containing Lactobacilli reuteri (DSM 17938 and ATCC PTA 5289) or placebo were dissolved intra-orally three times daily for 16 weeks, after which patients were followed up for 36 weeks. Mucosal symptoms, VAS pain, OLP severity score, plaque index (PI) and gingival index (GI), Candida count/carriage, and OC and/or need for symptomatic treatment were registered. Statistical significance was set at p Results No difference was observed between the groups during the intervention or follow-up in terms of recurrent OC (p = .966) or need for symptomatic treatment (p = 1.000). There was no difference in terms of Candida count (p = .96) or carriage over time (p = .511). GI decreased in the probiotic group and increased in the placebo group (p = .046). OLP severity score decreased in both groups during the study period (p = .039). Across the entire study period, the placebo group had higher VAS pain score (p = .037). Conclusions Probiotic intervention did not reduce recurrent OC or Candida count/carriage, but the study experienced recruitment problems, which may have influenced results. |
| Databáze: | OpenAIRE |
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