Assessment of micronucleus and oxidative stress in peripheral blood from malnourished children
| Autor: | Elsa Cervantes-Ríos, Rocío Ortiz-Muñiz, Mina Konigsberg-Fainstein, Jaime Graniel-Guerrero, Leonor Rodríguez Cruz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Antioxidant medicine.medical_treatment Medicine (miscellaneous) Physiology Micronuclei 010501 environmental sciences medicine.disease_cause 01 natural sciences Lipid peroxidation chemistry.chemical_compound Child Whole blood chemistry.chemical_classification Nutrition and Dietetics Micronucleus Tests biology Glutathione peroxidase food and beverages Micronuclei. Glutathione peroxidase Child Preschool Micronucleus test Female Medicina Superoxide dismutase Infections 03 medical and health sciences medicine Humans 0105 earth and related environmental sciences Glutathione Peroxidase business.industry Superoxide Dismutase Malnutrition nutritional and metabolic diseases Infant Blood Cell Count Oxidative Stress 030104 developmental biology chemistry Oxidative stress biology.protein Lipid Peroxidation Micronucleus business Malnourished children |
| Zdroj: | Nutrición Hospitalaria v.35 n.3 2018 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud instname Universidad Autónoma Metropolitana UAM Redalyc-UAM Nutrición Hospitalaria (España) Num.3 Vol.35 |
| ISSN: | 1699-5198 |
| Popis: | Introduction: malnutrition is one of the most common health problems among children in underdeveloped countries, including Mexico. Previous studies have indicated increased genetic damage in malnourished humans and animal models, but the essential mechanisms remain unclear. In the present study, we assessed the effects of malnutrition on the frequency of micronucleus (MN) in reticulocytes (RET) from the peripheral blood of well-nourished uninfected (WN), well-nourished infected (WNI), moderately malnourished infected (UNM) and severely malnourished infected (UNS) children. Moreover, lipid peroxidation and the antioxidant status were evaluated to investigate the role of oxidative processes in malnutrition-associated genotoxicity. Methods: the antioxidant status of the study population was determined by measuring superoxide dismutase (SOD) in the red blood cells and glutathione peroxidase (GPX) in whole blood. Results: the UNS and UNM groups have increased percentages of MN-RET compared to the WNI group. Moreover, the data showed a significant increase in lipid peroxidation and a decrease in erythrocyte SOD activity and GPX activity in the malnourished group compared to the well-nourished infected children. Conclusion: the data suggest that the antioxidant system was impaired in the cells of malnourished children and that oxidative stress causes a significant increase in DNA damage, as evaluated by the MN-RET frequency. |
| Databáze: | OpenAIRE |
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