Body surface area-based equivalent dose calculation in tree shrew
| Autor: | Yi-wei Feng, Wei Xia, An-zhou Tang, Lei Liu, Zong-jian Huang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Body surface area
Tupaia 0303 health sciences Multidisciplinary biology Equivalent dose Body Surface Area Tupaiidae Zoology biology.organism_classification Rats Tree shrew 03 medical and health sciences Experimental animal Tupaia belangeri 0302 clinical medicine Animals 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Science progress. 104(2) |
| ISSN: | 2047-7163 |
| Popis: | Tree shrew (Tupaia belangeri) is a promising experimental animal in biomedical research, but the equivalent doses of drugs between tree shrew and human and other animals has not been explored, which hinders its further application in a wider scope. The main objective of this article is to provide a method of equivalent dose conversion between tree shrews and other species based on body surface area (BSA). BSA of tree shrews were measured by Image J software, and then the average Km value of tree shrews was figured out based on the body weights and BSA, then the conversion coefficients of equivalent dose among tree shrew and other species of experimental animals were calculated based known data. The Km value of tree shrews was 0.105 ± 0.001. Through BSA conversion, the equivalent dose for tree shrews (D-ts) relative to rats was obtained by formula: D-ts = 1.36 × D-a (rats weighing 200 g as example), and the error was less than 10% when the BW of the tree shrew was 0.09 kg–0.15 kg. The coefficients of equivalent dose transferring from tree shrews to human and other species were calculated in article. These parameters could be used to determine a suitable dosing strategy for tree shrew studies. |
| Databáze: | OpenAIRE |
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