Effect of stress on basophil function in chronic idiopathic urticaria
| Autor: | E. R. Kaminski, S. M. Dyke, B. S. Carey |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent Hydrocortisone Urticaria Immunology Platelet Membrane Glycoproteins Adrenocorticotropic hormone Basophil Basophil degranulation Models Biological chemistry.chemical_compound Antigens CD Internal medicine medicine Humans Immunology and Allergy Aged CD63 Tetraspanin 30 business.industry Middle Aged Mast cell Hormones Basophils N-Formylmethionine Leucyl-Phenylalanine Basophil activation medicine.anatomical_structure Endocrinology chemistry Pituitary Gland Histamine H1 Antagonists business hormones hormone substitutes and hormone antagonists Histamine Hormone |
| Zdroj: | Clinical & Experimental Allergy. :071101015606002 |
| ISSN: | 1365-2222 0954-7894 |
| DOI: | 10.1111/j.1365-2222.2007.02864.x |
| Popis: | Summary Background Chronic idiopathic urticaria (CIU) is a distressing skin condition involving recurrent itchy hives lasting 6 weeks or longer. The mechanism involves mast cell and basophil degranulation, which releases inflammatory mediators including histamine. In our clinical practice, we have observed that the onset of CIU is often preceded by a major life event. Objective To investigate the role of the hormones of the hypothalamic–pituitary–adrenal (HPA) axis in the link between psychological stress and CIU. Methods Thirty people with CIU and 30 normal controls were recruited. A flow cytometric CD63 expression assay was used to quantify basophil activation, and serum cortisol concentrations were measured as an indication of stress. Results Both corticotrophin releasing factor (CRF) and adrenocorticotrophic hormone (ACTH) were shown to activate basophils. There was no significant difference between numbers of CIU patients and normal controls responding to CFR, ACTH or cortisol. However, the responses in the CIU patients were stronger than those in normal controls. There was also a trend towards higher serum cortisol concentrations in CIU patients. The basophil response to CRF and ACTH correlated with the serum cortisol concentration in normal controls, but not in CIU patients. Conclusions Although our data have not supported the hypothesis that stress makes a major contribution to CIU, the heightened basophil response to CFR and ACTH and higher levels of serum cortisol do suggest a derangement of the HPA axis in CIU. |
| Databáze: | OpenAIRE |
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