Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis
| Autor: | Rhonda R. Voskuhl, Sehyun Kim, M.A. Dalal, M. A. Verity, Stephanie M. Liva |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Encephalomyelitis Autoimmune Experimental Multiple Sclerosis Encephalomyelitis Autoimmune Diseases chemistry.chemical_compound Mice Immune system Pregnancy Internal medicine Demyelinating disease Medicine Animals reproductive and urinary physiology Autoimmune disease biology business.industry Estriol Experimental autoimmune encephalomyelitis Brain Myelin Basic Protein Th1 Cells medicine.disease Interleukin-10 Disease Models Animal Endocrinology chemistry Immunology biology.protein Female Neurology (clinical) Antibody business Estriol succinate hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neurology. 52(6) |
| ISSN: | 0028-3878 |
| Popis: | Objective: To evaluate the use of estriol in the treatment of experimental autoimmune encephalomyelitis (EAE) and other cell mediated autoimmune diseases. Background: Experimental autoimmune encephalomyelitis is a T helper 1 (Th1)-mediated autoimmune demyelinating disease that is a useful model for the study of immune responses in MS. Interestingly, both EAE and MS have been shown to be ameliorated during late pregnancy. Methods: Estriol, progesterone, and placebo pellets were implanted in mice during the effector phase of adoptive EAE. Disease scores were compared between treatment groups, and autoantigen-specific humoral and cellular responses were examined. Results: Estriol treatment reduced the severity of EAE significantly compared with placebo treatment whereas progesterone treatment had no effect. Estriol doses that induced serum estriol levels that approximated estriol levels during late pregnancy were capable of ameliorating disease. Estriol-treated EAE mice had significantly higher levels of serum antibodies of the immunoglobulin (Ig) G1 isotype specific for the autoantigen myelin basic protein (MBP). Further, MBP-specific T-lymphocyte responses from estriol-treated EAE mice were characterized by significantly increased production of the Th2 cytokine interleukin 10 (IL-10). T lymphocytes were shown to be the primary source of IL-10 within antigen-stimulated splenocyte populations. Conclusions: Estriol as a hormone involved in immune changes during pregnancy may provide a basis for the novel therapeutic use of estriol for MS and other putative Th1-mediated autoimmune diseases that improve during late pregnancy. |
| Databáze: | OpenAIRE |
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