The Pseudo-Pelger HuËt Cell—A New Permanent Radiation Biomarker
| Autor: | Patrick H. Ney, Carol J. Iddins, Ronald E. Goans, Nicholas Dainiak, Natalia I. Ossetrova |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Neutrophils Epidemiology Health Toxicology and Mutagenesis Population Cell Sensitivity and Specificity Ionizing radiation 03 medical and health sciences 0302 clinical medicine Radiation Monitoring Humans Dosimetry Medicine Radiology Nuclear Medicine and imaging education education.field_of_study business.industry Reproducibility of Results Radiation Exposure 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Biomarker (medicine) Biological Assay Female Analysis of variance Animal studies Pelger-Huet Anomaly Radioactive Hazard Release Dose rate business Nuclear medicine Biomarkers |
| Zdroj: | Health Physics. 112:252-257 |
| ISSN: | 0017-9078 |
| DOI: | 10.1097/hp.0000000000000618 |
| Popis: | Using archival peripheral blood slides obtained from patients in the 1958 Y-12 criticality accident, the authors have recently described the pseudo-Pelger Huet anomaly (PHA) in neutrophils as a new radiation-induced biomarker. The current work provides additional evidence that PHA is also a permanent biomarker, potentially useful in retrospective dosimetry. In the Y-12 cohort, the high dose group (n = 5, 2.98-4.61 Gy-Eq) exhibited 13.0 ± 0.85 % Pelger Huet cells (mean ± SEM) in the neutrophil population compared to 6.8 ± 1.6 % in the low dose group (n = 3, 0.29-0.86 Gy-Eq; p = 0.008). An age and gender-matched control group (n = 8) exhibited 3.6 ± 0.9 % PH cells. Results of a one-way ANOVA show that the high dose group is statistically different from both the low dose group and the control group (p = 0.002). In the Y-12 cohort, PHA appears |
| Databáze: | OpenAIRE |
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