Diagnostic accuracy of non-contrast quiescent-interval slice-selective (QISS) MRA combined with MRI-based vascular calcification visualization for the assessment of arterial stenosis in patients with lower extremity peripheral artery disease
Autor: | Akos Varga-Szemes, Ioannis Koktzoglou, Thomas M. Todoran, U. Joseph Schoepf, Pal Suranyi, Tilman Emrich, Robert R. Edelman, Megha Penmetsa, Stephen R. Fuller |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Contrast Media Constriction Pathologic Sensitivity and Specificity Article 030218 nuclear medicine & medical imaging Peripheral Arterial Disease 03 medical and health sciences 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Vascular Calcification Neuroradiology Computed tomography angiography medicine.diagnostic_test Arterial stenosis business.industry Ultrasound Angiography Digital Subtraction Reproducibility of Results Magnetic resonance imaging General Medicine Digital subtraction angiography medicine.disease Magnetic Resonance Imaging Stenosis Lower Extremity 030220 oncology & carcinogenesis Radiology business Magnetic Resonance Angiography Calcification |
Zdroj: | Eur Radiol |
ISSN: | 1432-1084 0938-7994 |
DOI: | 10.1007/s00330-020-07386-4 |
Popis: | The proton density–weighted, in-phase stack-of-stars (PDIP-SOS) MRI technique provides calcification visualization in peripheral artery disease (PAD). This study sought to investigate the diagnostic accuracy of a combined non-contrast quiescent-interval slice-selective (QISS) MRA and PDIP-SOS MRI protocol for the detection of PAD, in comparison with CTA and digital subtraction angiography (DSA). Twenty-six prospectively enrolled PAD patients (70 ± 8 years) underwent lower extremity CTA and 1.5-T or 3-T PDIP-SOS/QISS MRI prior to DSA. Two readers rated image quality and graded stenosis (≥ 50%) on QISS MRA without/with calcification visualization. Sensitivity, specificity, and area under the curve (AUC) were calculated against DSA. Calcification was quantified and compared between MRI and non-contrast CT (NCCT) using paired t test, Pearson’s correlation, and Bland-Altman analysis. Image quality ratings were significantly higher for CTA compared to those for MRA (4.0 [3.0–4.0] and 3.0 [3.0–4.0]; p = 0.0369). The sensitivity and specificity of QISS MRA, QISS MRA with PDIP-SOS, and CTA for ≥ 50% stenosis detection were 85.4%, 92.2%, and 90.2%, and 90.3%, 93.2%, and 94.2%, respectively, while AUCs were 0.879, 0.928, and 0.923, respectively. A significant increase in AUC was observed when PDIP-SOS was added to the MRA protocol (p = 0.0266). Quantification of calcification showed significant differences between PDIP-SOS and NCCT (80.6 ± 31.2 mm3 vs. 88.0 ± 29.8 mm3; p = 0.0002) with high correlation (r = 0.77, p |
Databáze: | OpenAIRE |
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