Anthoxanthin Polyphenols Attenuate AβOligomer-induced Neuronal Responses Associated with Alzheimer's Disease
| Autor: | McCall Rogers, Nicholas P. van der Munnik, John Will Reed, Melissa A. Moss, Steven Zebulon Vance, Kayla M. Pate |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant Protein Conformation medicine.medical_treatment Apoptosis Disease Biology Oligomer Article Neuroblastoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Line Tumor Physiology (medical) medicine Humans Pharmacology (medical) Apigenin Kaempferols Luteolin Pharmacology chemistry.chemical_classification Reactive oxygen species Amyloid beta-Peptides Tumor Necrosis Factor-alpha Mechanism (biology) Polyphenols Hydrogen Peroxide Peptide Fragments Cell biology Psychiatry and Mental health Neuroprotective Agents 030104 developmental biology chemistry Biochemistry Polyphenol Caspases Reactive Oxygen Species Kaempferol 030217 neurology & neurosurgery Intracellular |
| Zdroj: | CNS Neuroscience & Therapeutics. 23:135-144 |
| ISSN: | 1755-5930 |
| DOI: | 10.1111/cns.12659 |
| Popis: | SummaryAims Epidemiological evidence implicates polyphenols as potential natural therapeutics for Alzheimer's disease (AD). To investigate this prospect, five anthoxanthin polyphenols were characterized for their ability to reduce amyloid-β (Aβ) oligomer-induced neuronal responses by two mechanisms of action, modulation of oligomerization and antioxidant activity, as well as the synergy between these two mechanisms. Methods Anthoxanthin oligomerization modulation and antioxidant capabilities were evaluated and correlated with anthoxanthin attenuation of oligomer-induced intracellular reactive oxygen species (ROS) and caspase activation using human neuroblastoma cell treatments designed to isolate these mechanisms of action and to achieve dual-action. Results While modulation of oligomerization resulted in only minor reductions to neuronal responses, anthoxanthin antioxidant action significantly attenuated oligomer-induced intracellular ROS and caspase activation. Kaempferol uniquely exhibited synergism when the two mechanisms functioned in concert, leading to a pronounced reduction in both ROS and caspase activation. Conclusions Together, these findings identify the dominant mechanism by which these anthoxanthins attenuate Aβ oligomer-induced neuronal responses, elucidate their prospective synergy, and demonstrate the potential of anthoxanthin polyphenols as natural AD therapeutics. |
| Databáze: | OpenAIRE |
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