A Rare Association Between Leukocyte Adhesion Deficiency Type I and Psoriasis in Humans
| Autor: | Heba Abd-Allah, Dalia H. El-Ghoneimy, Zeinab A El-Sayed, Hanaa M. Afifi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty integumentary system business.industry Immunology Case Report hemic and immune systems CD18 psoriasis medicine.disease Neutrophilia Pathogenesis Immunopathology Psoriasis β2 integrins medicine Immunology and Allergy LAD-I Leukocytosis medicine.symptom business Psoriasiform Dermatitis Leukocyte adhesion deficiency |
| Zdroj: | Allergy, Asthma & Immunology Research |
| ISSN: | 2092-7355 |
| DOI: | 10.4168/aair.2011.3.2.138 |
| Popis: | The β2 integrins are expressed exclusively on leukocytes and participate in many immune and inflammatory processes. This subfamily comprises four heterodimeric glycoproteins with a common β-subunit, designated β2 (CD18). Spontaneous mutations of the CD18 gene result in leukocyte adhesion deficiency type I (LAD-I). Low level of CD18 expression has also been implicated in the pathogenesis of psoriasis. We here describe a child with recurrent skin infections without pus formation, persistent gingivitis and periodontitis. His blood counts showed persistent leukocytosis (neutrophilia). CD11b expression was defective on neutrophils, while that of CD18 was normal. So, our patient represents a mild variant of LAD-I with possible dysfunctional CD18. Moreover, he developed psoriasis with reduced CD18 expression on CD4(+) T-cells. Psoriasiform dermatitis has been described before in association with LAD-I, however, clinically and histologically confirmed psoriasis in association with LAD-I has been described only in CD18 hypomorphic mice. Therefore, our patient represents the first clinically and histopathologically documented association between LAD-I and psoriasis in humans. It lends support to the role of β2 integrins in the etiopathogenesis of psoriasis. |
| Databáze: | OpenAIRE |
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