Tropoelastin Implants That Accelerate Wound Repair
| Autor: | Yiwei Wang, Francia Garces-Suarez, Suzanne M. Mithieux, Elizabeth A. Carter, Alan Riboldi-Tunnicliffe, Kosuke Ohgo, Clair Baldock, Kristin K. Kumashiro, Le-Ping Yan, Wojciech Chrzanowski, Anthony S. Weiss, Christina Limantoro, Glenn A. Edwards, David Cookson, Kekini V. Kuppan, Behnaz Aghaei-Ghareh-Bolagh, Zhe Li, Peter K.M. Maitz |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Skin wound Open wounds Split-thickness Swine Biomedical Engineering Pharmaceutical Science Hydrogel Polyethylene Glycol Dimethacrylate Biomaterials 03 medical and health sciences Mice Tropoelastin Active component Absorbable Implants Medicine Animals Humans Autografts Wound Healing biology integumentary system Tissue Scaffolds business.industry Regeneration (biology) Dermis Resorption 030104 developmental biology Wounds biology.protein Blood Vessels Implant Epidermis business Wound healing Repair Biomedical engineering |
| Zdroj: | Mithieux, S M, Aghaei-Ghareh-Bolagh, B, Yan, L, Kuppan, K V, Wang, Y, Garces-Suarez, F, Li, Z, Maitz, P K, Carter, E A, Limantoro, C, Chrzanowski, W, Cookson, D, Riboldi-Tunnicliffe, A, Baldock, C, Ohgo, K, Kumashiro, K K, Edwards, G & Weiss, A S 2018, ' Tropoelastin Implants That Accelerate Wound Repair ', Advanced Healthcare Materials . https://doi.org/10.1002/adhm.201701206 |
| ISSN: | 2192-2659 |
| Popis: | A novel, pure, synthetic material is presented that promotes the repair of full-thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair. Key to the technology is the use of a novel heat-based, stabilized form of human tropoelastin which allows for tunable resorption. This implantable material contributes a tailored insert that can be shaped to the wound bed, where it hydrates to form a conformable protein hydrogel. Significant benefits in the extent of wound healing, dermal repair, and regeneration of mature epithelium in healthy pigs are demonstrated. The implant is compatible with initial co-treatment with full- and split-thickness skin grafts. The implant's superiority to sterile bandaging, commercial hydrogel and dermal regeneration template products is shown. On this basis, a new concept for a prefabricated tissue repair material for point-of-care treatment of open wounds is provided. |
| Databáze: | OpenAIRE |
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